Effect of Aerva lanata against oxalate mediated free radical toxicity inurolithiasis

다국어 초록 (Multilingual Abstract)

This study was undertaken to evaluate the antioxidant potential of A. lanata on oxalate mediated
free radical toxicity in ethylene glycol induced calcium oxalate urolithic rats. Calcium oxalate
(CaOX) stone was induced by 0.75% ethylene glycol in drinking water for 28 days. From 29th day
onwards, the CaOX urolithic rats were treated with A. lanata aqueous suspension (2,000 mg/kg
body weight/dose/day) orally for another 28 days. At the end of experimental periods the
animals were sacrificed, samples were collected and analyzed the lipid peroxidation product,
protein oxidation product, enzymatic and non-enzymatic antioxidants in normal and
experimental groups. Lipid peroxidation and protein oxidation products were significantly
elevated while enzymatic and non-enzymatic antioxidant levels were significantly decreased in
ethylene glycol induced CaOX urolithic rats when compared with control rats. The above
alterations were reverted to near control in rats treated with aqueous suspension of A. lanata. This
study suggests that A. lanata could prevent the free radical formation from calcium oxalate
urolithiasis in rats and protecting the renal cells from oxidative injury.

다국어 초록 (Multilingual Abstract)

This study was undertaken to evaluate the antioxidant potential of A. lanata on oxalate mediated
free radical toxicity in ethylene glycol induced calcium oxalate urolithic rats. Calcium oxalate
(CaOX) stone was induced by 0.75% ethylene glycol in drinking water for 28 days. From 29th day
onwards, the CaOX urolithic rats were treated with A. lanata aqueous suspension (2,000 mg/kg
body weight/dose/day) orally for another 28 days. At the end of experimental periods the
animals were sacrificed, samples were collected and analyzed the lipid peroxidation product,
protein oxidation product, enzymatic and non-enzymatic antioxidants in normal and
experimental groups. Lipid peroxidation and protein oxidation products were significantly
elevated while enzymatic and non-enzymatic antioxidant levels were significantly decreased in
ethylene glycol induced CaOX urolithic rats when compared with control rats. The above
alterations were reverted to near control in rats treated with aqueous suspension of A. lanata. This
study suggests that A. lanata could prevent the free radical formation from calcium oxalate
urolithiasis in rats and protecting the renal cells from oxidative injury.

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