Nonsyndromic Multiple Basal Cell Carcinomas

다국어 초록 (Multilingual Abstract)

Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. All lesions were completely removed by surgery.
The pathologic results showed lesions consistent with BCC and some lesions consistent with actinic keratosis. After 8 months, the patient presented with skin lesions in bilateral temporal areas and left cheek area. Surgical excision of the lesions was performed, and the biopsy results were squamous cell carcinoma in situ and actinic keratosis. In Case 2, a 43-year-old woman presented with multiple skin lesions on the face, scalp, right chest, abdomen and right leg. All lesions were completely removed by surgery. Pathologic evaluation confirmed the diagnosis of BCC. BCC is rarely metastatic, but it can lead to severe disfiguration or destruction. It is important to diagnose and treat BCC at an early stage.

참고문헌 (Reference)

1 Cowey CL, "Targeted therapy for advanced Basal-cell carcinoma: vismodegib and beyond" 3 : 17-31, 2013

2 Alghamdi Y, "Skin tags as a presenting sign of basal cell nevus syndrome in three sisters of the same family" 28 : 132-134, 2008

3 McNaughton SA, "Role of dietary factors in the development of basal cell cancer and squamous cell cancer of the skin" 14 : 1596-1607, 2005

4 Robinson JK, "Risk of developing another basal cell carcinoma: a 5-year prospective study" 60 : 118-120, 1987

5 Lara F, "Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors" 92 : 58-62, 2017

6 Ramachandran S, "Presentation with multiple cutaneous basal cell carcinomas:association of glutathione S-transferase and cytochrome P450genotypes with clinical phenotype" 8 : 61-67, 1999

7 Christensen KN, "Outcomes of basal cell carcinomas directly invading the parotid gland" 41 : 390-396, 2015

8 Happle R, "Nonsyndromic type of hereditary multiple basal cell carcinoma" 95 : 161-163, 2000

9 Malhotra AK, "Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5%cream" 25 : 488-491, 2008

10 Ahn SK, "Multiple basal cell carcinoma associated with keratoacanthoma" 33 : 277-280, 1992

11 Maydan E, "Management of cutaneous neoplasms invading the parotid gland" 32 : 1209-1213, 2006

12 Bath-Hextall FJ, "Interventions for basal cell carcinoma of the skin" (1) : CD003412-, 2007

13 Zak-Prelich M, "Environmental risk factors predisposing to the development of basal cell carcinoma" 30 (30): 248-252, 2004

14 Farley RL, "Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve, and temporal bone" 32 : 307-315, 2006

15 Lu Y, "A new mutation of PTCH gene in a Chinese family with nevoid basal cell carcinoma syndrome" 121 : 118-121, 2008