은행나무 접목묘의 모수 지역별에 따른 엽 추출물의 flavonol glycosides 및 terpene lactones 함량 특성 = Characteristics of Flavonol Glycosides and Terpene Lactones Contents from the Leaf Extract of Grafted Ginkgo biloba According to the Sites of Their Mother Trees

다국어 초록 (Multilingual Abstract)

Ginkgo tree, Ginkgo biloba L. is a dioecious, coniferous species which is valuable for timber, nuts and high tolerance to air pollution. Also, this species is one of the tree species increasingly explored by medicinal chemists due to its pharmaceutically active leaf terpenes and flavonoids. To clarify the contents of flavonol glycosides and terpene lactones in the leaf, the clonal grafts having the large fruit and high productivity were planted in the same place, and compared with the sites effect of their mother trees. The flavonol glycosides contents showed significant difference among sites of their mother trees; The leaf extracts collected from Jeonnam and Chungnam had higher amounts of flavonol glycosides than those collected from Gyeonggi, China and Chungbuk. However, no significant difference was found in the amount of terpene lactones of extracts among sites of their mother tree. Superior seed bearing trees contented more terpene lactones with significant difference than those of the control trees,but the flavonol glycoside contents didn`t show significant difference between both of them. The contents of terpene lactones in Ginkgo tree leaf were less affected on sites effect than that of flavonol glycosides. In these result, we can suppose that selection of Ginkgo tree getting higher contents of terpene lactones is to get high extraction efficiency for useful substances from the leaf extract.

참고문헌 (Reference)

1 "허훈 및 김영중 기내배양한 은행 유식물에서의 ginkgolide의 생산" 304-308, 1993

2 "천연물화학 연구법" 서울대학교 437-, 1999

3 "의약품 등 기준 및 시험방법" 약업신문사 1286-, 1998

4 "은행잎중 flavonol glycoside 성분의 계절별 함량 변화에 관한 연구" 47-53, 1993

5 "은행잎의 flavonoid 성분에 관한 연구" 111-120, 1990

6 "성에 따른 은행잎 중의 ginkgolides 함량의 변화" 20-23, 1994

7 "The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers" 151 : 416-423, 2000

8 "Selective adsorption of flavonoid compounds from the leaf extract of Ginkgo biloba L" 11 : 553-556, 1997

9 "Ontogenic aspects of ginkgolide production in Ginkgo biloba" 232-239, 1992

10 "Introduction to flavonoids" Hardwood academic publishers 503-, 1998

11 "Influence of an extract of Ginkgo biloba on cerebral blood flow and metabolism" 2327-2334, 1986

12 "Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level" 69 : 2327-2336, 2001

13 "Ginkgo biloba (EGB 761) improves microcirculation after warm ischemia of the rat liver" 33 : 979-981, 2001

14 "Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers" 589-593, 1990

15 "Distribution of ginkolides and terpenoid biosynthetic activity in Ginkgo biloba" 48 : 89-92, 1998

16 "Chemical analysis of leaves and extracts" 967 : 21-55, 2002

17 "Bilobalide and neuroprotection" 46 (46): 565-568, 2002

18 "Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761)." 108 : 969-978, 2001

19 "A living fossil." 108 : 341-342, 2000