miR‐429 is involved in regulation of NF‐κBactivity by targeting IKKβ and suppresses oncogenic activity in cervical cancer cells

다국어 초록 (Multilingual Abstract)

Dysregulation of microRNAs (miRNAs) can contribute to tumorigenesis in cancers. In this study, we found that miR‐429 was downregulated in cervical cancer (CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKKβ was a novel target gene of miR‐429 and ectopic expression of IKKβ abrogated the phenotypes induced by miR‐429. When IKKβ was downregulated by miR‐429, nuclear factor κB (NF‐κB) pathway activation, interleukin‐6 (IL‐6), and interferon‐β (IFN‐β) production were decreased in CC cells. These findings indicate that miR‐429 is involved in regulation of the NF‐κB pathway by targeting IKKβ and functions as a tumor suppressor in cervical carcinogenesis.