Restless Legs Syndrome in Patients on Hemodialysis: Symptom Severity and Risk Factors

다국어 초록 (Multilingual Abstract)

Background and Purpose Restless legs syndrome (RLS) is a sleep disorder that frequently
occurs in dialysis patients, which disturbs the sleep and reduces the quality of life. The aim of
this study was to determine the risk factors for RLS in dialysis patients.
Methods Patients who visited any of four outpatient dialysis clinics between September 2005
and May 2006 were included in this study. The diagnosis of RLS and the severity assessment
were made using the criteria described by the International Restless Legs Syndrome Study
Group. We collected basic demographic data, clinical information, and laboratory findings, and
then analyzed their association with various aspects of RLS using univariate and multivariate
analyses.
Results RLS was present in 46 (28.0%) of 164 dialysis patients. We found no significant risk
factor for inducing RLS. The predialysis serum blood urea nitrogen (BUN) level in the dialysis
patients with RLS was significantly correlated with RLS symptom severity.
Conclusions Predialysis BUN is related to RLS symptom severity. Further studies on the
underlying mechanism are needed.

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