Antihypertensive activity of Zingiber officinale and Korean ginseng in experimentally induced hypertension in rats

다국어 초록 (Multilingual Abstract)

We investigated the antihypertensive effect of Pet ether extract (PE) of ginger rhizome; its toluene
fraction (TF) and Korean ginseng extract (KGE) in deoxycorticosterone acetate (DOCA) – salt
induced and fructose induced hypertensive rats. In DOCA model, DOCA (25 mg/kg, once a
week; s.c) was administered in uninephrectomised animals for 4 w. PE (50 mg/kg/day; p.o), TF
(10 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were evaluated for their antihypertensive
effect. In the fructose model, drinking water was replaced with fructose (10%) for five weeks to
induce hypertension. PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were assessed for its
antihypertensive effect in fructose model. After completion of the treatment schedule, vascular
reactivity to various agonists like 5-HT, noradrenaline, adrenaline, phenylbiguanide and acetylcholine
were recorded in rats of both the models. A cumulative dose response curve (CDRC) of 5-HT was
carried out in isolated rat fundus strip of the fructose induced hypertensive rats. Chronic
administration of PE (50 mg/kg/day; p.o), TF (10 mg/kg/day; p.o), and KGE (30 mg/kg/day; p.o)
significantly reduced the blood pressure in DOCA salt whereas PE (50 mg/kg/day; p.o) and KGE (30
mg/kg/day; p.o) reduced the blood pressure in fructose induced hypertensive rats. Treatment with
PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) in fructose model for five weeks shifted the
CDRC towards the right on rat fundus. The mechanism of action may partly involve the
serotonergic antagonistic property.

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