先天性梅毒의 病理組織學的 檢索 = Pathology of Congenital Syphilis

다국어 초록 (Multilingual Abstract)

Pathoanatomical and histopathological studies were made on seven autopsy cases of congenital syphilis which were bacteriologically or serologically confirmed.
Seven cases of congenital syphilis were all new born infants that expired within a month. Clinically, dyspnea and skin rashes were the most pronounced findings. Hepatosplenomegaly was marked. Blood examination showed severe anemia in all.
Grossly, heart, liver, spleen and lungs were generally increased in weight. They were uniformly firm and revealed grayish hue.
Microscopical findings were principally composed of diffuse visceral fibrosis, inflammatory cell infiltration and widespread extramedullary hematopoisis. Visceral fibrosis was most marked in the pancreas, lung and liver, although spleen, kidneys, thymus and adrenals were also involved.
Pertinent autopsy findings are as follows:
Skin shows maculo-papular lesion.
Heart shows endocardial fibrosis in one case and the others show capillary congestion with endothelial swelling.
Lungs are enlarged and uniformly firm. Alveolar septa show diffuse fibrosis and cell infiltration showing the picture of so called "pneumonia alba".
Liver section is characterized by extensive periportal fibrosis and diffuse hematopoiesis. These fibrotic changes are more marked in right lobe especially along ductus venosus. Giant cells are frequently observed and this picture was discussed along the line of giant cell transformation of hepatic cells.
Spleen is enlarged and shows diffuse increase of fibrous connective tissue in addition to extramedullary hemopoisis.
Pancreas shows rather extensive fibrosis together with acinar atrophy and inflammatory cellular aggregates. Langerhans islets appear to be enlarge in some cases.
Adrenal glands shows fibrosis in cortex together with capsular fibrosis. However, inflammatory cell infiltration is rather meager. Adrenal cytomegalia which is