Facile Synthetic Routes to Prepare α-Muricholic Acid, Hyocholic Acid, and Their Taurine Conjugates

다국어 초록 (Multilingual Abstract)

α-Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of α-muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.

참고문헌 (Reference)

1 Rolo, A. P., 57 : 177-185, 2000

2 Xue, C.-B., 60 : 946-952, 1995

3 Matsubara, T., 53 (53): 2698-2707, 2012

4 Iida, T., 30 (30): 1267-1269, 1989

5 Iida, T., 55 : 530-538, 1990

6 Yoshimura, T., 58 : 52-58, 1993

7 Hsia, S. L., 227 : 597-601, 1957

8 Zollner, G., 156 : 7-27, 2009

9 Watkins, W. J., 13 : 4241-4244, 2003

10 Cerea, P., 63 : 4108-4119, 2007

11 Dayal, B., 8 : 861-862, 1995

12 Parenti, M, "Process for the preparation of tauroursodeoxycholic acid" PCT Int. Appl 2008

13 Arosio, R., "Preparation of taurocholic acids" Eur. Pat. Appl 1994

14 Zhang, B., "Faming Zhuanli Shenqing Gongkai Shuomingshu: CN 1896091"

15 Deng, Y., "Faming Zhuanli Shenqing Gongkai Shuomingshu: CN 101307088"