The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

다국어 초록 (Multilingual Abstract)

Musculoskeletal pain is the most common pain reported by patients. Platelet-rich plasma (PRP) is widely used to treat musculoskeletal pain. However, the efficacy of PRP to treat this pain remains controversial. This review highlights the application of PRP in the treatment of musculoskeletal pain. PRP treatment appears to reduce pain and improve function in patients with musculoskeletal pain. However, there are limitations to the currently published studies. These limitations include the PRP preparation methods, type of activators, types of pathology to be treated, methods and times of administration, and association of PRP with other treatments.

참고문헌 (Reference)

1 Haigler MC, "Use of platelet-rich plasma, platelet-rich growth factor with arthrocentesis or arthroscopy to treat temporomandibular joint osteoarthritis : systematic review with meta-analyses" 149 : 940-952, 2018

2 Chen X, "Use of platelet-rich plasma for the improvement of pain and function in rotator cufftears : a systematic review and meta-analysis with bias assessment" 48 : 2028-2041, 2020

3 Baig Mirza Zain ; Abdullah Umm E Hani ; Muhammad Aun ; Aziz Abeer ; Syed Maryam Jamil ; Darbar Aneela, "Use of Platelet-Rich Plasma in Treating Low Back Pain: A Review of the Current Literature" 대한척추외과학회 15 (15): 117-126, 2021

4 Hardy R, "To improve pain and function, platelet-rich plasma injections may be an alternative to surgery for treating lateral epicondylitis : a systematic review" 37 : 3360-3367, 2021

5 Solakoglu Ö, "The use of plasma rich in growth factors(PRGF)in guided tissue regeneration and guided bone regeneration : a review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans" 231 : 151528-, 2020

6 Shen L, "The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis : systematic review and meta-analysis of randomized controlled trials" 12 : 16-, 2017

7 Sepúlveda F, "The role of physiatry in regenerative medicine : the past, the present, and future challenges" 7 (7): S76-S80, 2015

8 Cross M, "The global burden of hip and knee osteoarthritis : estimates from the global burden of disease 2010 study" 73 : 1323-1330, 2014

9 Chen X, "The efficacy of platelet-rich plasma on tendon and ligament healing : a systematic review and meta-analysis with bias assessment" 46 : 2020-2032, 2018

10 Chen XT, "The efficacy of platelet-rich plasma for improving pain and function in lateral epicondylitis : a systematic review and meta-analysis with risk-of-bias assessment" 37 : 2937-2952, 2021

11 Giovannetti de Sanctis E, "The efficacy of injections for partial rotator cufftears : a systematic review" 10 : 51-, 2020

12 Schneider BJ, "The effectiveness of intradiscal biologic treatments for discogenic low back pain : a systematic review" 22 : 226-237, 2022

13 Hawker GA, "The assessment of musculoskeletal pain" 35 (35): 8-12, 2017

14 Galatz LM, "Tendon regeneration and scar formation : the concept of scarless healing" 33 : 823-831, 2015

15 Scott A, "Sports and exercise-related tendinopathies : a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium(ISTS)Vancouver 2012" 47 : 536-544, 2013

16 Barman A, "Single intra-articular platelet-rich plasma versus corticosteroid injections in the treatment of adhesive capsulitis of the shoulder : a cohort study" 98 : 549-557, 2019

17 Wu CC, "Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis" 32 : 5847-5854, 2011

18 Alves R, "Randomized placebo-controlled, double-blind, half-head study to assess the efficacy of platelet-rich plasma on the treatment of androgenetic alopecia" 42 : 491-497, 2016

19 Marks R, "Qigong and musculoskeletal pain" 21 : 59-, 2019

20 Leanne Dupley ; Charalambos P. Charalambous, "Platelet­-Rich Plasma Injections as a Treatment for Refractory Patellar Tendinosis: A Meta­Analysis of Randomised Trials" 대한슬관절학회 29 (29): 165-171, 2017

21 Moraes VY, "Platelet-rich therapies for musculoskeletal soft tissue injuries" 2014 : CD010071-, 2014

22 Kaushik A, "Platelet-rich plasma: the journey so far!" 11 : 685-692, 2020

23 Kon E, "Platelet-rich plasma(PRP)to treat sports injuries : evidence to support its use" 19 : 516-527, 2011

24 Li A, "Platelet-rich plasma vs corticosteroids for elbow epicondylitis: a systematic review and meta-analysis" 98 : e18358-, 2019

25 Belk JW, "Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis : a systematic review and meta-analysis of randomized controlled trials" 49 : 249-260, 2021

26 Vetrano M, "Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes" 41 : 795-803, 2013

27 Alkhatib N, "Platelet-rich plasma versus corticosteroids in the treatment of chronic plantar fasciitis : a systematic review and meta-analysis of prospective comparative studies" 59 : 546-552, 2020

28 Hurley ET, "Platelet-rich plasma versus corticosteroids for plantar fasciitis : a systematic review of randomized controlled trials" 8 : 2325967120915704-, 2020

29 Kemp JA, "Platelet-rich plasma versus corticosteroid injection for the treatment of lateral epicondylitis : a systematic review of systematic reviews" 16 : 597-605, 2021

30 Gautam VK, "Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation" 23 : 1-5, 2015

31 Arirachakaran A, "Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis : systematic review and network meta-analysis" 17 : 101-112, 2016

32 Bos-Mikich A, "Platelet-rich plasma therapy and reproductive medicine" 35 : 753-756, 2018

33 Dhillon RS, "Platelet-rich plasma therapy : future or trend?" 14 : 219-, 2012

34 Mohammed S, "Platelet-rich plasma injections : an emerging therapy for chronic discogenic low back pain" 4 : 115-122, 2018

35 Zotti F, "Platelet-rich plasma in treatment of temporomandibular joint dysfunctions : narrative review" 20 : 277-, 2019

36 Liddle AD, "Platelet-rich plasma in the treatment of patellar tendinopathy : a systematic review" 43 : 2583-2590, 2015

37 Fei X, "Platelet-rich plasma has better mid-term clinical results than traditional steroid injection for plantar fasciitis : a systematic review and meta-analysis" 107 : 103007-, 2021

38 Urits I, "Platelet-rich plasma for the treatment of low back pain : a comprehensive review" 23 : 52-, 2019

39 Bousnaki M, "Platelet-rich plasma for the therapeutic management of temporomandibular joint disorders : a systematic review" 47 : 188-198, 2018

40 A Hamid MS, "Platelet-rich plasma for rotator cufftendinopathy : a systematic review and meta-analysis" 16 : e0251111-, 2021

41 Everts P, "Platelet-rich plasma : new performance understandings and therapeutic considerations in 2020" 21 : 7794-, 2020

42 El-Sharkawy H, "Platelet-rich plasma : growth factors and pro-and anti-inflammatory properties" 78 : 661-669, 2007

43 Anitua E, "Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients" 46 : 1769-1772, 2007

44 Linden MD, "Platelet physiology" 992 : 13-30, 2013

45 Sakalys D, "Plasma rich in growth factors injection effectiveness for myofascial pain treatment in masticatory muscles : randomised controlled trial" 47 : 796-801, 2020

46 Dickinson RN, "Physical therapy versus natural history in outcomes of rotator cufftears : the Rotator CuffOutcomes Workgroup(ROW)cohort study" 28 : 833-838, 2019

47 Unlu MC, "Peritendinous injection of platelet-rich plasma to treat tendinopathy : a retrospective review" 51 : 482-487, 2017

48 Christian RA, "Patellar tendinopathy: recent developments toward treatment" 72 : 217-224, 2014

49 Lo IK, "Partial-thickness rotator cufftears : clinical and imaging outcomes and prognostic factors of successful nonoperative treatment" 9 : 191-197, 2018

50 Zhou Y, "PRP treatment efficacy for tendinopathy : a review of basic science studies" 2016 : 9103792-, 2016

51 Andriolo L, "Nonsurgical treatments of patellar tendinopathy : multiple injections of platelet-rich plasma are a suitable option : a systematic review and meta-analysis" 47 : 1001-1018, 2019

52 Casser HR, "Musculoskeletal pain" 29 : 486-488, 2015

53 Bendinelli P, "Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes : mechanisms of NF-κB inhibition via HGF" 225 : 757-766, 2010

54 Block JA, "Management of knee osteoarthritis : what internists need to know" 105 : 367-385, 2021

55 Knezevic NN, "Low back pain" 398 : 78-92, 2021

56 Chou R, "Low back pain" 174 : ITC113-ITC128, 2021

57 Tschon M, "Lights and shadows concerning platelet products for musculoskeletal regeneration" 3 : 96-107, 2011

58 Tosti R, "Lateral epicondylitis of the elbow" 126 : 357-, 2013

59 Nowak Z, "Intramuscular injections and dry needling within masticatory muscles in management of myofascial pain : systematic review of clinical trials" 18 : 9552-, 2021

60 Jain D, "Intradiscal platelet-rich plasma injection for discogenic low back pain and correlation with platelet concentration : a prospective clinical trial" 21 : 2719-2725, 2020

61 McLarnon M, "Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis : systematic review and meta-analysis" 22 : 550-, 2021

62 Vannabouathong C, "Intra-articular injections in the treatment of symptoms from ankle arthritis : a systematic review" 39 : 1141-1150, 2018

63 Derwich M, "Interdisciplinary approach to the temporomandibular joint osteoarthritis-review of the literature" 56 : 225-, 2020

64 Kelley MJ, "Frozen shoulder : evidence and a proposed model guiding rehabilitation" 39 : 135-148, 2009

65 Middleton KK, "Evaluation of the effects of platelet-rich plasma(PRP)therapy involved in the healing of sports-related soft tissue injuries" 32 : 150-163, 2012

66 Fahy KE, "Efficacy of platelet-rich plasma on symptom reduction in patellar tendinopathy" 21 : 232-234, 2021

67 Xuan Z, "Efficacy of platelet-rich plasma for low back pain : a systematic review and meta-analysis" 81 : 529-534, 2020

68 Karabaş Ç, "Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis : a prospective, randomized-controlled study" 67 : 462-472, 2021

69 Ling Y, "Effects of platelet-rich plasma in the treatment of plantar fasciitis: a meta-analysis of randomized controlled trials" 97 : e12110-, 2018

70 Zhao J, "Effects and safety of the combination of platelet-rich plasma(PRP)and hyaluronic acid(HA)in the treatment of knee osteoarthritis : a systematic review and meta-analysis" 21 : 224-, 2020

71 Lin MT, "Effectiveness of platelet-rich plasma injection in rotator cufftendinopathy: a systematic review and meta-analysis of randomized controlled trials" 10 : 189-, 2020

72 Chiew SK, "Effectiveness and relevant factors of platelet-rich plasma treatment in managing plantar fasciitis : a systematic review" 21 : 38-, 2016

73 Paget LD, "Effect of platelet-rich plasma injections vs placebo on ankle symptoms and function in patients with ankle osteoarthritis : a randomized clinical trial" 326 : 1595-1605, 2021

74 Kearney RS, "Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion Achilles tendinopathy : a randomized clinical trial" 326 : 137-144, 2021

75 Sanapati J, "Do regenerative medicine therapies provide long-term relief in chronic low back pain : a systematic review and metaanalysis" 21 : 515-540, 2018

76 Sousa BM, "Different treatments in patients with temporomandibular joint disorders: a comparative randomized study" 56 : 113-, 2020

77 Bliddal H, "Definition, pathology and pathogenesis of osteoarthritis" 182 : V06200477-, 2020

78 Dadgostar H, "Corticosteroids or platelet-rich plasma injections for rotator cufftendinopathy : a randomized clinical trial study" 16 : 333-, 2021

79 Repetto I, "Conservative treatment of ankle osteoarthritis : can platelet-rich plasma effectively postpone surgery?" 56 : 362-365, 2017

80 Thu AC, "Comparison of ultrasound-guided platelet-rich plasma injection and conventional physical therapy for management of adhesive capsulitis : a randomized trial" 48 : 300060520976032-, 2020

81 Yilmaz O, "Comparison of the efficacy of botulinum toxin, local anesthesia, and platelet-rich plasma injections in patients with myofascial trigger points in the masseter muscle" 79 : 88-, 2021

82 Shahzad HF, "Comparison of functional outcome between intra-articular injection of corticosteroid versus platelet-rich plasma in frozen shoulder : a randomized controlled trial" 13 : e20560-, 2021

83 Li FL, "Comparison of autologous platelet-rich plasma and chitosan in the treatment of temporomandibular joint osteoarthritis : a retrospective cohort study" 79 : 324-332, 2021

84 Sun SF, "Comparing efficacy of intraarticular single crosslinked Hyaluronan(HYAJOINT Plus)and platelet-rich plasma(PRP)versus PRP alone for treating knee osteoarthritis" 11 : 140-, 2021

85 Smith J, "Comparing PRP injections with ESWT for athletes with chronic patellar tendinopathy" 24 : 88-89, 2014

86 Lin MT, "Comparative effectiveness of injection therapies in rotator cufftendinopathy : a systematic review, pairwise and network meta-analysis of randomized controlled trials" 100 : 336-349, 2019

87 Muthu S, "Comparative analysis of leucocyte poor vs leucocyte rich platelet-rich plasma in the management of lateral epicondylitis : systematic review & meta-analysis of randomised controlled trials" 19 : 96-107, 2021

88 Cook CS, "Clinical update : why PRP should be your first choice for injection therapy in treating osteoarthritis of the knee" 11 : 583-592, 2018

89 Simental-Mendía M, "Clinical efficacy of platelet-rich plasma in the treatment of lateral epicondylitis : a systematic review and meta-analysis of randomized placebo-controlled clinical trials" 39 : 2255-2265, 2020

90 de Mos M, "Can platelet-rich plasma enhance tendon repair? : a cell culture study" 36 : 1171-1178, 2008

91 Woolf AD, "Burden of major musculoskeletal conditions" 81 : 646-656, 2003

92 Xie X, "Biology of platelet-rich plasma and its clinical application in cartilage repair" 16 : 204-, 2014

93 Cugat R, "Biologic enhancement of cartilage repair : the role of platelet-rich plasma and other commercially available growth factors" 31 : 777-783, 2015

94 Varshney A, "Autologous platelet-rich plasma versus corticosteroid in the management of elbow epicondylitis : a randomized study" 7 : 125-128, 2017

95 Hosny N, "Assessment of vascular endothelial growth factor in fresh versus frozen platelet rich plasma" 2015 : 706903-, 2015

96 Godoy-Santos AL, "Ankle osteoarthritis" 56 : 689-696, 2020

97 Alves R, "A review of platelet-rich plasma : history, biology, mechanism of action, and classification" 4 : 18-24, 2018

98 Wu J, "A prospective study comparing platelet-rich plasma and local anesthetic(LA)/corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome" 17 : 914-924, 2017

99 Cao Y, "A narrative review of the research progress and clinical application of platelet-rich plasma" 10 : 4823-4829, 2021