Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover. It has been claimed for several pharmacological effects including anti-alcohol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Pue...
Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover. It has been claimed for several pharmacological effects including anti-alcohol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Puerariae Radix effects, an activity-guided purification of active substance on alcohol dehydrogenase (ADH) was carried-out. The most active compound was isolated as puerarin (C21H2OO9), molecular weight 416. Puerarin inhibited ADH noncompetitively against ethanol or NAD+.