β-Glucan 분획을 제거한 신령버섯 균사체 액체 배양액(β-glucan-free HEAB)으로부터 새로운 형태의 α-glucosidase 활성저해 소재를 개발하였다. β-Glucan-free HEAB를 용매분획하여 10 mg/ml 농도에서 α-glucos...
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https://www.riss.kr/link?id=A82722969
2011
Korean
KCI등재
학술저널
1579-1585(7쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
β-Glucan 분획을 제거한 신령버섯 균사체 액체 배양액(β-glucan-free HEAB)으로부터 새로운 형태의 α-glucosidase 활성저해 소재를 개발하였다. β-Glucan-free HEAB를 용매분획하여 10 mg/ml 농도에서 α-glucos...
β-Glucan 분획을 제거한 신령버섯 균사체 액체 배양액(β-glucan-free HEAB)으로부터 새로운 형태의 α-glucosidase 활성저해 소재를 개발하였다. β-Glucan-free HEAB를 용매분획하여 10 mg/ml 농도에서 α-glucosidase 저해활성을 측정한 결과 EA분획이 가장 강한 활성(61.6% 저해)을 나타내었고, 경구혈당강하제인 acarbose (5 mg/ml; 39.5% 저해) 보다 강하였다. EA분획을 더 분획하여 α-glucosidase 저해활성이 80.4%인 분획을 얻었다. 이 분획에는 α-glucosidase 저해 활성을 갖는 daidzin 및 genistin과 같은 isoflavone과 isoflavone의 sugar conjugate된 물질이 함유되어 있었다. 따라서 α-glucosidase 저해 활성을 나타내는 β-glucan-free HEAB나 EA분획물은 인체의 혈당을 조절할 수 있는 소재로 활용될 수 있을 것이다.
다국어 초록 (Multilingual Abstract)
Natural anti-diabetic semipurified ethyl acetate fraction was isolated from the submerged-liquid culture of Agaricus blaze Murill (AB) in a medium containing soybean flakes. Hot-water extract of AB (HEAB) was prepared by extraction at 121℃ for 60 mi...
Natural anti-diabetic semipurified ethyl acetate fraction was isolated from the submerged-liquid culture of Agaricus blaze Murill (AB) in a medium containing soybean flakes. Hot-water extract of AB (HEAB) was prepared by extraction at 121℃ for 60 min, followed by filtering through a filter presser filled with diatomate. The β-glucan-free HEAB, which was a supernatant fraction from HEAB by
precipitation in an 80% ethanol solution, was fractionated into hexane, chloroform, ethyl acetate, and butanol fractions. The inhibition of the α-glucosidase activity by fractions was 59.0, 17.0, 61.6, and 37.9%, respectively, suggesting that ethyl acetate fraction was the most active. A subfraction having a strong α-glucosidase inhibitory activity (80.4%) was isolated from the ethyl acetate fraction. This subfraction contained isoflavones (genistin and daidzin) and their conjugates with sugars as potent inhibiters of α-glucosidase activity. These results suggest that the ethyl acetate fraction or HEAB containing isoflavones and their sugars conjugates could be useful sources for controlling blood sugar levels in humans.
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Effects of Resistance Training on Skeletal Muscle GLUT-4 Protein and LDH Isozyme Expression in Rats
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |