HDL-Associated Paraoxonase 1 as a Bridge between Postmenopausal Osteoporosis and Cardiovascular Disease

다국어 초록 (Multilingual Abstract)

The association of postmenopausal osteoporosis (PMOP) with both atherosclerosis and vascular/valvular calcification is well known. Recently, ample evidence has suggested a common etiologic factor, namely, reduced HDL-associated paraoxonase 1 (PON1) activity, as a causative factor in the development of PMOP and cardiovascular disease (CVD). This common etiologic factor not only contributes to atherosclerotic diseases but also to PMOP following an almost identical mechanism including dysfunctional HDL and lipid oxidation. According to recent studies, lipid oxidation might improve osteoblastic transformation of vascular cells and obstruct such transformation in bone cells. The primary objective of this current review was to summarize the evidence revealing the role of HDL-associated PON1 enzyme in PMOP. Additionally, the review aimed to address some of the subjects that need further investigation in order to define whether hyperhomocysteinemia and sensitivity to lipid oxidation may be risk factors for PMOP.

참고문헌 (Reference)

1 Weitzmann MN, "The role of inflammatory cytokines, the RANKL/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis" 2013 : 125705-, 2013

2 Srinivasan PC, "The role of inflammatory cytokines and the RANKL-RANK-OPG molecular triad in periodontal bone loss-a review" S13 : 007-, 2013

3 Tekkesin MS, "The role of RANK/RANKL/OPG signalling pathways in osteoclastogenesis in odontogenic keratocysts, radicular cysts, and ameloblastomas" 5 : 248-253, 2011

4 Goettsch C, "The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells" 152 : 4915-4926, 2011

5 Yilmaz N, "Relationship between paraoxonase and homocysteine:crossroads of oxidative diseases" 8 : 138-153, 2012

6 Yilmaz N, "Relation of parity and homocysteine to bone mineral density of postmenopausal women" 52 : 49-56, 2006

7 Sood R, "Prescribing menopausal hormone therapy: an evidence-based approach" 6 : 47-57, 2014

8 Liu L, "Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification" 32 : 1491-1497, 2011

9 Yang H, "Oxidized low density lipoprotein, stem cells, and atherosclerosis" 11 : 85-, 2012

10 Mazière C, "Oxidized low density lipoprotein enhanced RANKL expression in human osteoblastlike cells. Involvement of ERK, NFkappaB and NFAT" 1832 : 1756-1764, 2013

11 Graham LS, "Oxidized lipids enhance RANKL production by T lymphocytes:implications for lipid-induced bone loss" 133 : 265-275, 2009

12 Almeida M, "Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription" 282 : 27298-27305, 2007

13 Kang NN, "Oxidative stress and the risk of osteoporosis: the role of dietary polyphenols and nutritional supplements in postmenopausal Women"

14 Zhang F, "Ox-LDL promotes migration and adhesion of bone marrow-derived mesenchymal stem cells via regulation of MCP-1 expression" 2013 : 691023-, 2013

15 Haynes DR, "Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint" 40 : 623-630, 2001

16 Baucom, K, "Osteoporosis: The Need for Prevention and Treatment" 3 : 2-29, 2014

17 Xiong J, "Osteocyte RANKL: new insights into the control of bone remodeling" 27 : 499-505, 2012

18 Lv H, "Methylation of the promoter A of estrogen receptor alpha gene in hBMSC and osteoblasts and its correlation with homocysteine" 355 : 35-45, 2011

19 Tsuda E, "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis" 234 : 137-142, 1997

20 Toptaş B, "Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients" 40 : 6519-6524, 2013

21 Eren E, "Homocysteine, Paraoxonase-1 and Vascular Endothelial Dysfunction: Omnibus viis Romam Pervenitur" 8 : CE01-CE04, 2014

22 Yilmaz N, "Homocysteine oxidative stress and relation to bone mineral density in post-menopausal osteoporosis" 21 : 353-357, 2009

23 Kim BJ, "High serum total homocysteine levels accelerate hip bone loss in healthy premenopausal women and men" 52 : 56-62, 2013

24 Eren E, "High density lipoprotein and it's dysfunction" 6 : 78-93, 2012

25 Eren E, "Heart valve disease: the role of calcidiol deficiency, elevated parathyroid hormone levels and oxidative stress in mitral and aortic valve insufficiency" 19 : 34-39, 2014

26 SoonHoNam, "H2O2 Enhances Ca2+ Release from Osteoblast Internal Stores" 연세대학교의과대학 43 (43): 229-235, 2002

27 Eren E, "Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis" 2013 : 792090-, 2013

28 Lobo V, "Free radicals, antioxidants and functional foods: Impact on human health" 4 : 118-126, 2010

29 Weitzmann MN, "Estrogen deficiency and bone loss: an inflammatory tale" 116 : 1186-1194, 2006

30 Suzuki SM, "Engineering human PON1 in an E. coli expression system" 660 : 37-45, 2010

31 Choi HK, "Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis" 23 : 524-536, 2013

32 Yilmaz N, "Diagnostic value of biochemical markers of bone turnover and postmenopausal osteoporosis" 37 : 137-143, 1999

33 Yilmaz N, "Decreased paraoxonase 1, arylesterase enzyme activity, and enhanced oxidative stress in patients with mitral and aortic valve insufficiency" 59 : 597-604, 2013

34 Choe Y, "Continuously generated H2O2 stimulates the proliferation and osteoblastic differentiation of human periodontal ligament fibroblasts" 113 : 1426-1436, 2012

35 Hamel P, "Characterization of oxidized low-density lipoprotein-induced hormesis-like effects in osteoblastic cells" 294 : C1021-C1033, 2008

36 Almeida M, "Basic biology of skeletal aging: role of stress response pathways" 68 : 1197-1208, 2013

37 Yamada Y, "Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese" 48 : 469-475, 2003

38 Zhang H, "Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women:a meta-analysis" 289 : 1003-1009, 2014

39 Almeida M, "Aging mechanisms in bone" 1 : 102-, 2012

40 Kajarabille N, "A new insight to bone turnover: role of ω-3 polyunsaturated fatty acids" 2013 : 589641-, 2013