Membranoproliferative glomerulonephritis in a patient with chronic brucellosis = Membranoproliferative glomerulonephritis in a patient with chronic brucellosis

다국어 초록 (Multilingual Abstract)

Brucellosis is the most common zoonotic disease in Greece, with an endemic distribution and can affect any organ. Infiltration of the renal parenchyma causes acute and chronic interstitial nephritis with granulomas, whereas renal glomeruli are rarely affected. The disease has been sporadically reported, and it causes various histopathologic patterns. Herein, we describe the case of a 39-year-old stock breeder with a history of recurrent episodes of bacteremia caused by Brucella melitensis over a period of 3 years. Two months after the last episode of bacteremia, he presented with mild renal insufficiency, nephrotic range proteinuria, and microscopic hematuria. A renal biopsy revealed membranoproliferative glomerulonephritis with a pattern of focal-segmental nodular sclerosis and moderate tubulointerstitial fibrosis. The patient received antimicrobial and corticosteroid therapy with partial remission of the nephrotic syndrome.

참고문헌 (Reference)

1 Masani N, "Update on membranoproliferative GN" 9 : 600-608, 2014

2 Eyre JWH, "The milroy lectures on melitensis septic©¡mia (Malta or Mediterranean fever)" 171 : 1747-1752, 1908

3 Ceylan K, "Renal involvement in Brucella infection" 73 : 1179-1183, 2009

4 Ardalan MR, "Rapidly progressive glomerulonephritis in a patient with brucellosis" 21 : 1743-1744, 2006

5 Bruce D, "Observations on Malta fever" 1 : 1101-1105, 1889

6 Hermida Lazcano I, "Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis" 51 : e257-e259, 2005

7 Margolis G, "Glomerulonephritis occurring in experimental brucellosis in dogs" 23 : 983-993, 1947

8 Kusztal M, "Dissecting aneurysm of the thoracic aorta in a patient with nephrotic syndrome and brucellosis" 39 : 641-645, 2007

9 Yrivarren JL, "Cryoglobulinemia and cutaneous vasculitis in human brucellosis" 7 : 471-474, 1987

10 Colmenero JD, "Complications associated with Brucella melitensis infection: a study of 530 cases" 75 : 195-211, 1996

11 Young EJ, "Brucellosis: current epidemiology, diagnosis, and management" 15 : 115-128, 1995

12 Madkour MM, "Brucellosis" Butterworth-Heinemann 152-159, 1989

13 Altiparmak MR, "Brucella glomerulonephritis: review of the literature and report on the first patient with brucellosis and mesangiocapillary glomerulonephritis" 34 : 477-480, 2002

14 Bakri FG, "Brucella glomerulonephritis resulting in end-stage renal disease: a case report and a brief review of the literature" 40 : 529-533, 2008

15 Elzouki AY, "Brucella endocarditis associated with glomerulonephritis and renal vasculitis" 10 : 748-751, 1996