<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The survival of patients with head and neck squamous cell carcinoma (HNSCC) can be affe...
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https://www.riss.kr/link?id=A107522845
2016
-
SCI,SCIE,SCOPUS
학술저널
e3403
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The survival of patients with head and neck squamous cell carcinoma (HNSCC) can be affe...
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The survival of patients with head and neck squamous cell carcinoma (HNSCC) can be affected not only by progression of the original cancer or occurrence of a second cancer but also by noncancer health event (NCHE). In this study, we evaluated the prognostic significance of early NCHEs in HNSCC patients after definitive radiotherapy (RT) or chemoradiotherapy (CRT).</P><P>The prospective study cohort comprised 190 HNSCC patients who underwent definitive RT (n = 75) or CRT (n = 115). An early NCHE was defined as an event requiring hospital readmission of the patient within 12 months after treatment. Univariate and multivariate analyses were performed to identify clinicopathologic factors associated with early NCHEs, and competing and all-cause mortalities.</P><P>Thirty-three patients suffered an NCHE (17.3%) and 8 succumbed to a competing cause of mortality (4.2%). Twenty-two (11.6%) patients had an early NCHE: respiratory (22.8%), cerebrovascular (13.7%), gastrointestinal (13.7%), and others (50.0%). In multivariate analysis, hypoalbuminemia (<I>P</I> = 0.022, hazard ratio [HR] = 3.66, 95% confidence interval [CI] = 1.21–11.1), chemotherapy (<I>P</I> = 0.047, HR = 3.02, 95% CI = 1.01–8.98), and tumor recurrence (<I>P</I> = 0.024, HR = 2.66, 95% CI = 1.14–6.22) were independent predictors of an early NCHE. Patients with early NCHEs were at high risk of competing mortality (<I>P</I> < 0.001, HR = 22.6, 95% CI = 4.21–121.00) and all-cause mortality (<I>P</I> = 0.002, HR = 4.44, 95% CI = 1.76–11.2).</P><P>Early NCHEs are a major contributor to competing and all-cause mortality in HNSCC patients receiving RT or CRT. The risk factors identified could be used to predict early NCHEs.</P></▼2>
Serum Clusterin as a Prognostic Marker of Chronic Spontaneous Urticaria