<P><B>Abstract</B></P> <P>Pectolinarin and pectolinarigenin have been reported to be major compounds in <I>Cirsium setidens</I>. In the present study, we demonstrated inhibitory effects of pectolinarin and pe...
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https://www.riss.kr/link?id=A107440796
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2017
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SCI,SCIE,SCOPUS
학술저널
765-772(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>Pectolinarin and pectolinarigenin have been reported to be major compounds in <I>Cirsium setidens</I>. In the present study, we demonstrated inhibitory effects of pectolinarin and pe...
<P><B>Abstract</B></P> <P>Pectolinarin and pectolinarigenin have been reported to be major compounds in <I>Cirsium setidens</I>. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from <I>C. setidens</I> on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in <I>C. setidens</I> water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of <I>C. setidens</I> water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in <I>C. setidens</I> water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pectolinarigenin has more potent inhibitory effects than pectolinarin on melanin synthesis in melan-a cells. </LI> <LI> Pectolinarigenin has more potent inhibitory effects than pectolinarin on expression of melanogenesis-related genes. </LI> <LI> Pectolinarigenin has inhibitory effect on melanin production in a reconstructed human skin model. </LI> <LI> Microwave irradiation under 1% acetic acid conditions is optimal to convert pectolinarin into pectolinarigenin. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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