Antibacterial, Antifungal and Anticonvulsant Evaluation of Novel Newly Synthesized 1-[2-(1H-Tetrazol-5-yl)ethyl]-1H-benzo[d][1, 2,3]triazoles

다국어 초록 (Multilingual Abstract)

Several novel 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized
by the condensation of 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) and appropriate
acid chlorides. 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) was synthesized by
reacting 3-(1H-benzo[d][1,2,3]triazol-1-yl)propanenitrile with sodium azide and ammonium
chloride in the presence of dimethylformamide. The synthesized compounds were characterized
by IR and PMR analysis. The titled compounds were evaluated for their in vitro antibacterial
and antifungal activity by the cup plate method and anticonvulsant activity evaluated by the
maximal electroshock induced convulsion method in mice. All synthesized compounds exhibited
moderate antibacterial activity against Bacillus subtilis and moderate antifungal activity
against Candida albicans. Compounds 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-
1-yl)(4-aminophenyl)methanone 3d and 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-
1-yl)(2-aminophenyl)methanone 3e elicited excellent anticonvulsant activity.

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