급성 간 손상시 Fat Storing Cell의 변화에 관한 형태학적 검색 = A Morphologic Study of Fat Storing Cell in Acute Liver Injury

다국어 초록 (Multilingual Abstract)

The present study was undertaken to investigate the role of fat storing cell(FSC) in ICR mice with acute liver injury induced intraperitoneal injection of carbon tetrachloride, using light and electron microscopy. During the first two days after poisoning, centrilobular necrosis and proliferation of FSCs were most prominent. From the 3rd day onward, extracellular collagen fibers increased gradually. Ultrastructually, proliferated FSC contained well developed rough endoplasmic reticulum (rEr) and a small amount of lipid droplets with a few mitochondria, and typical collagen fibrils were frequently seen in close proximity to these cells after the fifth day. This study suggest that fibrosis in the acutely damaged liver is due to connective tissue synthesis by the activation of FSC and the FSC is the precursor of the fibroblast.