Trend of Olfactory and Gustatory Dysfunction in COVID-19 Patients in a Quarantine Facility

다국어 초록 (Multilingual Abstract)

Background: Olfactory and gustatory dysfunction has been reported as characteristic symptoms of coronavirus disease 2019 (COVID-19). This study evaluated olfactory and gustatory dysfunction in mild COVID-19 patients using validated assessment methods.
Methods: A prospective surveillance study was conducted for mild COVID-19 patients who were isolated at the Gyeonggi International Living and Treatment Support Center (LTSC), Korea.
Olfactory function was assessed using the Korean version of the Questionnaire of Olfactory Disorders (QOD) and Cross-Cultural Smell Identification Test (CC-SIT). Gustatory function was assessed using an 11-point Likert scale and 6-n-propylthiouracil, phenylthiocarbamide, and control strips. All patients underwent nasal and oral cavity endoscopic examination.
Results: Of the 62 patients at the LTSC, 15 patients (24.2%) complained of olfactory or gustatory dysfunction on admission. Four of 10 patients who underwent functional evaluation did not have general symptoms and 2 were asymptomatic. The mean short version of QOD-negative statements and QOD-visual analogue scale scores were 13 ± 6 and 4.7 ± 3.6, respectively. The mean CC-SIT score was 8 ± 2. No patients showed anatomical abnormalities associated with olfactory dysfunction on endoscopic examination. The mean Likert scale score for function was 8 ± 2, and there were no abnormal lesions in the oral cavity of any patient.
Conclusions: The prevalence of olfactory and gustatory dysfunction was 24.2% in mild COVID-19 patients. All patients had hyposmia due to sensorineural olfactory dysfunction, which was confirmed using validated olfactory and gustatory evaluation methods and endoscopic examination. Olfactory and gustatory dysfunction may be characteristic indicators of mild COVID-19.

참고문헌 (Reference)

1 Rothe C, "Transmission of 2019-nCoV infection from an asymptomatic contact in Germany" 382 (382): 970-971, 2020

2 Chang WI, "The relationship between phenylthiocarbamide(PTC)and 6-n-propylthiouracil(PROP)taster status and taste thresholds for sucrose and quinine" 51 (51): 427-432, 2006

3 Gent JF, "Sweetness of sucrose, neohesperidin dihydrochalcone, and saccharin is related to genetic ability to taste the bitter substance 6-n-propylthiouracil" 7 (7): 265-272, 1983

4 Eliezer M, "Sudden and complete olfactory loss of function as a possible symptom of COVID-19" 146 (146): 674-675, 2020

5 Moein ST, "Smell dysfunction : a biomarker for COVID-19" 10 (10): 944-950, 2020

6 Choi WR, "Reliability and validity of the Korean version of the Questionnaire of Olfactory Disorders" 8 (8): 1481-1485, 2018

7 Yonghyun Lee, "Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients" 대한의학회 35 (35): 1-6, 2020

8 Arons MM, "Presymptomatic SARS-CoV-2infections and transmission in a skilled nursing facility" 382 (382): 2081-2090, 2020

9 Hall MJ, "PTC taste blindness and the taste of caffeine" 253 (253): 442-443, 1975

10 Frasnelli J, "Olfactory dysfunction and daily life" 262 (262): 231-235, 2005

11 Lechien JR, "Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease(COVID-19) : a multicenter European study" 277 (277): 2251-2261, 2020

12 이종목, "Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report" 대한의학회 35 (35): 1-4, 2020

13 Gane SB, "Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?" 58 (58): 299-301, 2020

14 Suzuki M, "Identification of viruses in patients with postviral olfactory dysfunction" 117 (117): 272-277, 2007

15 Baig AM, "Evidence of the COVID-19 virus targeting the CNS : tissue distribution, host-virus interaction, and proposed neurotropic mechanisms" 11 (11): 995-998, 2020

16 Doty RL, "Development of the 12-item Cross-Cultural Smell Identification Test(CCSIT)" 106 (106): 353-356, 1996

17 Cavazzana A, "Detection thresholds for quinine, PTC, and PROP measured using taste strips" 276 (276): 753-759, 2019

18 Leach EJ, "Comparison of bitterness of caffeine and quinine by a time–intensity procedure" 11 (11): 339-345, 1986

19 Whitcroft KL, "Clinical diagnosis and current management strategies for olfactory dysfunction : a review" 145 (145): 846-, 2019

20 Guan WJ, "Clinical characteristics of coronavirus disease 2019in China" 382 (382): 1708-1720, 2020

21 Zhang JJ, "Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China" 75 (75): 1730-1741, 2020

22 Cohen L, "Chemotherapy-induced nausea and vomiting : incidence and impact on patient quality of life at community oncology settings" 15 (15): 497-503, 2007

23 Yan CH, "Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms" 10 (10): 806-813, 2020

24 Russell B, "Anosmia and ageusia are emerging as symptoms in patients with COVID-19: what does the current evidence say?" 14 : ed98-, 2020

25 Zhu N, "A novel coronavirus from patients with pneumonia in China, 2019" 382 (382): 727-733, 2020