Comparison of Immunomodulatory Effects of the Cell Extracts from Two Different Variants of Saccharomyces cerevisiae

다국어 초록 (Multilingual Abstract)

Probiotic yeast variants including Saccharomyces cerevisiae and Saccharomyces boulardii have proven their effectiveness in the treatment of many gastrointestinal diseases including acute diarrhea and bacterial infection. The yeast cell wall is composed of functional polysaccharides such as b-glucan, mannans, and chitin which have beneficial effects on human health. Particularly, the b-glucans and mannans has gained interest in the food industry as nutritional supplements and ingredients for functional food. Saccharomyces boulardii is believed to be a variant strain of S. cerevisiae and has been commercialized as a food supplement promoting the health of the intestinal tract. To evaluate the health-promoting effects of S. boulardii strains when compared to that of S. cerevisiae, we examined in vitro the immunomodulatory effect of the yeast cell extracts from S. cerevisiae and S. boulardii by measuring the production of IL-6, TNF-ɑ, and nitric oxide (NO) levels in macrophage cell line Raw 264.7.