Fungal Allergen Propensity Study Confirmed Through Multiple Allergosorbent Chemiluminescent Assay

다국어 초록 (Multilingual Abstract)

Background: Exposure and sensitization to fungal allergens can evoke the development and worsen allergic diseases.
Many patients with allergies show multiple positive reactions to different allergens.
Objective: The purpose of this study was to analyze the relationship between fungal allergens that are mostly found in South Korea and other positive reactions to the allergens of the multiple allergosorbent simultaneous test chemiluminescent assay (MAST-CLA).
Methods: We enrolled 1,040 (588 men, 452 women) patients who showed positive reactions to three fungi, namely, Alternaria alternata, Aspergillus fumigatus, and Cladosporium herbarum, using MAST-CLA at Daegu Catholic University Medical Center from January 2010 to July 2017. The epidemiology and relationship between positive reactions to multiple fungal allergens and positive reactions to the allergens of the MAST-CLA were investigated.
Results: A. alternata was the most common fungal species, followed by C. herbarum and A. fumigatus (78.8% vs.
52.1% vs. 20.1%). Patients who showed positive reactions to all fungal allergens had 4.97 other antigens on average.
Statistically significant results were obtained when comparing positive reactions to all fungal allergens to other allergens (Spearman correlation coefficient = 0.129, p < 0.05).
Conclusion: Patients should be educated on allergic diseases caused by other antigens if they are sensitized to fungal antigens.

참고문헌 (Reference)

1 유영인, "알레르기성 비염의 기인성 항원에 대한 고찰：중복 감작의 분포" 대한이비인후과학회 46 (46): 48-53, 2003

2 이은주, "아토피 피부염 환자의 MAST 화학발광법에 의한 알레르겐 검사 성적과 임상 평가와의 상관관계" 대한피부과학회 41 (41): 197-206, 2003

3 Wioletta A., "Żukiewicz-Sobczak. The role of fungi in allergic diseases" 30 : 42-45, 2013

4 Simon-Nobbe B, "dermatophytes. The spectrum of fungal allergy" 145 : 58-86, 2008

5 Beaumont F, "Volumetric aerobiological survey of conidial fungi in the North-East Netherlands. Ⅰ. Seasonal patterns and the influence of metrological variables" 40 : 173-180, 1985

6 Scalabrin DM, "Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects" 104 : 1273-1279, 1999

7 Mothes N, "Transition from a botanical to a molecular classification in tree pollen allergy: Implications for diagnosis and therapy" 135 : 357-373, 2004

8 Bush RK, "The role and abatement of fungal allergens in allergic diseases" 107 : 430-440, 2001

9 Kivity S, "The association of perennial rhinitis with Trichophyton infection" 22 : 498-500, 1992

10 Mari A, "Sensitization to fungi: epidemiology, comparative skin tests, and IgE reactivity of fungal extracts" 33 : 1429-1438, 2003

11 Fukutomi Y, "Sensitization to fungal allergens:resolved and unresolved issues" 64 : 321-331, 2015

12 Corsico R, "Prevalence of sensitization to Alternaria in allergic patients in Italy" 80 : 71-76, 1998

13 Nolles G, "Prevalence of immunoglobulin E for fungi in atopic children" 31 : 1564-1570, 2001

14 Spitzauer S, "Major cat and dog allergens share IgE epitopes" 99 : 100-106, 1997

15 김현수, "MAST CLA 알레르기 검사에서 동시 양성 알레르겐의 분석" 대한진단검사의학회 25 (25): 448-456, 2005

16 Neukirch C, "Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study" 103 : 709-711, 1999

17 Torricelli R, "Ingestive and inhalantive allergy to the mushroom Boletus edulis" 52 : 747-751, 1997

18 Dales RE, "Influence of ambient fungal spores on emergency visits for asthma to a regional children's hospital" 162 : 2087-2090, 2000

19 Katz Y, "Indoor survey of moulds and prevalence of mould atopy in Israel" 29 : 186-192, 1999

20 Nissen D, "IgE-sensitization to cellular and culture filtrates of fungal extracts in patients with atopic dermatitis" 81 : 247-255, 1998

21 Ezeamuzie CI, "IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment" 121 : 300-307, 2000

22 Gupta R, "Identification of cross-reactive proteins amongst different Curvularia species" 127 : 38-46, 2002

23 Shin JH., "Fungus and allergy" 9 : 13-23, 1999

24 Crameri R, "Fungi: the neglected allergenic sources" 69 : 176-185, 2014

25 D'Amato G, "Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy. A European multicenter study promoted by the Subcommittee on Aerobiology and Environmental Aspects of Inhalant Allergens of the European Academy of Allergology and Clinical Immunology" 52 : 711-716, 1997

26 Lee SR, "Evaluation of the MAST-CLA allergy system (Korea IgE panel) for diagnosis of atopic allergy" 15 : 469-477, 1995

27 Matsson P, "Evaluation methods and analytical performance characteristics of immunologic assays for human immunoglobulin E (IgE) antibodies of defined allergen specificities"

28 Bogacka E, "Effect of fungi on human health" 8 : 175-178, 2001

29 Yun YY, "Cross-reactivity between pollens in patients sensitized to multiple pollens" 19 : 584-593, 1999

30 Crameri R, "Cross-reactivity among fungal allergens: A clinically relevant phenomenon?" 52 : 99-106, 2008

31 Scheynius A, "Atopic eczema/dermatitis syndrome and Malassezia" 127 : 161-169, 2002

32 Yang SE, "Analysis of MAST chemiluminescent assay (MAST CLA) results performed in Asan medical center" 18 : 606-606, 1998

33 Helbling A, "Allergy to basidiomycetes" 81 : 28-47, 2002

34 Woodfolk JA., "Allergy and dermatophytes" 18 : 30-43, 2005

35 Lacey J., "Allergy and allergic diseases" Blackwell Science 858-887, 1998

36 Ferreira F, "Allergic cross-reactivity: from gene to clinic" 59 : 243-267, 2004

37 Knutsen AP, "Allergic bronchopulmonary Aspergillosis in asthma and cystic fibrosis" 2011 : 843763-, 2011

38 Lim HS, "Allergen pattern using MAST CLA test in Korean pediatric patients" 21 : 292-297, 2001

39 Park KI, "Allergen frequencies on MAST CLA by age groups using new Korean panel" 21 : 243-249, 1999

40 온정윤, "Allergen Sensitization Pattern by Sex: A Cluster Analysis in Korea" 대한피부과학회 29 (29): 735-741, 2017

41 Oh JW, "Aerobiological study for airborne pollen and mold in Kuri-shi, Kyunggi-Do" 7 : 57-68, 1997

42 D'Amato G, "Aerobiologic and clinical aspects of mould allergy in Europe" 50 : 870-877, 1995

43 D'Amato G1, "Aerobiol Aerobiologic and clinical aspects of mould allergy in Europe" 76 : 819-825, 1995