고지방식이 유도 비만 마우스에서 Lactobacillus plantarum L-14의 체지방 감소 효과 = Protective Effects of Lactobacillus plantarum L-14 Supplementation Against High-fat Diet-induced Obesity and Metabolic Dysfunction in Mice

다국어 초록 (Multilingual Abstract)

This study aimed to evaluate the efficacy of Lactobacillus plantarum L-14 (L-14) supplementation in reducing body fat in high-fat diet (HFD)-induced obese mice. Mice were assigned to either a normal control diet or HFD, receiving varying doses of L-14 medium (ML, 2.5 × 108 cfu/ mouse/day; MH, 5 × 108 cfu/mouse/day) and L-14 cell pellets (PL, 5 × 108 cfu/mouse/day; PH, 2 × 109 cfu/mouse/day) over a period of 7 weeks. The results showed significant reductions in body weight gain, food efficiency, and white adipose tissue weight in mice supplemented with L-14 compared to HFD-induced obese mice. Notably, the PH group showed substantial suppression of body weight gain by 17.44% and a 37.9% decrease in epididymal fat pads in HFD-fed mice. L-14 supplementation also normalized alanine aminotransferase and aspartate transaminase levels, alongside improvements in fasting hyperglycemia and dyslipidemia. Furthermore, L-14 treatment ameliorated insulin resistance, evidenced by restored insulin, leptin, and adiponectin levels.
Additionally, L-14 mitigated hepatic steatosis by reducing fat droplet deposition and malondialdehyde levels, an oxidative stress biomarker, in HFD-fed mice. These results collectively indicate the protective effects of L-14 against HFD-induced obesity and associated metabolic diseases.