Treatment of Complete Spinal Cord Injury Patients receiving Autologous Bone Marrow Cell Transplatation and Bone Marrow Stimulation with Granulocyte Macrophag-Colony Stimulating Factor

다국어 초록 (Multilingual Abstract)

Objective : The transplantation of bone marrow cells into the injured spinal cord improves neurologic functions in
experimental animals. However, it is unclear whether bone marrow cells can similarly improve the neurologic
functions of complete spinal cord injury patients. To study their therapeutic effects in human spinal cord injury
(SCI), we transplante autologous bone marrow cells into the SCI sites and administer granulocyte macrophagecolony
stimulating factor (GM-CSF) in three complete SCI patients.
Methods : Bone marrow cell transplantation with GM-CSF administration was performed on two patients
(patients1 and 2), wherein concentrated bone marrow cell pastes were injected into the injury area using a sterile
21 gauge fine needle. The total volume of bone marrow cells injected was 1.8ml (cell concentration 1.1X106/ul).
Patient 3 was administered GM-CSF only. The follow up periods were 5 months (patient 1), 4 months (patient 2)
and 6 months (patient 3).
Results : Sensory improvements were followed immediately after the operations. Sensory recovery in the sacral
segment was noticed at 3 weeks (patient 1), 13 days (patient 2) and at 2 months (patient 3) postoperatively.
Significant motor improvements were noticed at 3 months in patients 1 and 2, and at 4 months in patient 3. All
three patients showed neurologic improvements at the last follow up 5,4 and 6months respectively (Frankel grade
C, AIS grade C).
Conclusion : Treatment of SCI patients with autologous bone marrow cell transplantation and GM-CSF
administration shows some beneficial effects during the early postoperative periods. However, long-term and more
comprehensive clinical studies are required.

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