Effects of exercise and microbiota transplant on the memory of obesity-induced mice

목차 (Table of Contents)

• Abstract
• INTRODUCTION
• MATERIALS AND METHODS
• Experiment animals
• Treadmill exercise protocol
• Fecal microbiota transplantation
• Glucose tolerance test
• Step-down avoidance test
• Morris water maze task
• Tissue preparation
• Western blotting for brain-derived neurotrophic factor and tropomyosin receptor kinase B
• Immunohistochemistry for glial fibrillary acidic protein
• Collection of fecal samples, sequencing and metagenomic analysis
• Data analysis
• RESULTS
• The effects of exercise and microbiome transplantation on body weight and blood glucose levels
• The effects of exercise and microbiome transplantation on short-term memory and spatial learning memory
• The effects of exercise and microbiome transplantation on BDNF and TrkB expression in the hippocampus
• The effects of exercise and microbiome transplantation on GFAP-positive cells in the hippocampal dentate gyrus
• The effects of exercise and microbiome transplantation in the gut microbiome
• DISCUSSION
• CONFLICT OF INTEREST
• ACKNOWLEDGMENTS
• REFERENCES