It was well known that the antigenic structure of the enteric bacteria forms a complex mosaic which often results in antigenic inter-relationship between different genera and species. Disease caused by one of the enteric bacteria may influence host im...
It was well known that the antigenic structure of the enteric bacteria forms a complex mosaic which often results in antigenic inter-relationship between different genera and species. Disease caused by one of the enteric bacteria may influence host immunity to the other enteric infection.
To investigate the immunological aspects to the enteric infections, polyvalent vaccine of Es. coli was prepared from 4 strains of Es. coli.
Following immunization of polyvalent vaccine of Es. coli in rabbit, agglutinin titers of serum, bactericidal activities of serum and phagocytosis of immune macrophages to enteric bacteria (Es. coli, Sh. dysenteriae and S. typhi) were followed.
Results were as follows.
1) Agglutinin titers to Es. coli antigen were significantly higher in immune sera of polyvalent Es. coli vaccine than in control sera.
2) Agglutinin titers to both Sh. dysenteriae antigen and S. typhi antigen were higher in immune sera than in control sera.
3) The enhancements of antibacterial activities to Es. coli were more noticeable in immune sera than in control sera.
4) The enhancements of antibacterial activities to both S. typhi and Sh. dysenteriae were increased slightly in immune sera over that of control sera.