Transplant physicians’ perceptions of cord blood transplantation in Korea: a questionnaire survey

다국어 초록 (Multilingual Abstract)

Background Although bone marrow (BM) or mobilized peripheral blood (PB) is frequently used as the source of hematopoietic stem cells, hematopoietic stem cell transplantation (HSCT) using cord blood (CB) is gradually gaining popularity in many countries. However, BM or PB is still preferred over CB in Korea. Therefore, we tried to assess the awareness of CB transplantation (CBT) among domestic HSCT physicians and develop strategies for boosting its utilization by administering questionnaires to some of these physicians.
Methods A direct questionnaire survey was conducted using the “Audience Response System” among 301 members who attended the annual meeting of the Korean Society of Blood and Marrow Transplantation. The data were analyzed for only 67 board certified physicians who were directly involved in HSCT activities.
Results The poor outcomes resulting from insufficient experience in CBT was designated by the physicians as the main reason for the low domestic implementation of HSCT using CB.
Other reasons identified in the survey were distrust in the quality and management of domestic CB and the high cost of obtaining CB.
Conclusion Increasing the use of donated CB would foremost require increasing the inventory of donated CB containing a sufficient cell number for CBT and securing structured quality control of the CB banks. In addition, it would be necessary to minimize CB supply costs and continue to provide academic data, including CBT guidelines, so that clinicians could perform CBT with more confidence.

참고문헌 (Reference)

1 Ballen KK, "Umbilical cord blood transplantation: the first 25 years and beyond" 122 : 491-498, 2013

2 "Transplants by cell source, 1990-2013"

3 "The law for cord blood management and research"

4 Lee YH, "Successful sibling cord blood stem cell transplantation for relapsed acute mixed lineage leukemic" 34 : 471-476, 1999

5 "Status of storage and transplantation of cord blood and an itemized account of patient's charges using cord blood"

6 "Information system for searching unrelated hematopoietic stem cell donors" Comprehensive Management System for Disease and Health

7 "Growth of the cord blood registry"

8 Yoo KH, "Current status of pediatric umbilical cord blood transplantation in Korea: a multicenter retrospective analysis of 236 cases" 86 : 12-17, 2011

9 "Cord blood banking introduction-State of the art"

10 Barker JN, "Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies" 115 : 1843-1849, 2010

11 Laroche V, "Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samples" 45 : 1909-1916, 2005

12 "Annual and cumulative incidence of unrelated hematopoietic stem cell transplantation according to the stem cell sources"

13 Lee YH, "Analysis of stored and transplanted cord blood units from KoreaCORD: reappraisal of banking guidelines and selection strategy" 53 : 123-127, 2013