대장직장 선종성 폴립발생 부위에 따른 관련 요인의 비교 = A Case-Control Study on Risk Factors of Colorectal Adenomatous Polyp by sites

다국어 초록 (Multilingual Abstract)

The level of oxidative tissue damage caused by free radicals generated from ethanol oxidation was determined in the myocardium of chronic ethanol fed-rats and the protective action of various radical scavenging enzymes was monitored, also. Adult male Sprague-Dawley rats were given ethanol in an amount of 36% of total calories via Lieber-DeCarli liquid diet for 6 weeks. Control group was pair-fed with the diet containing isocaloric amount of dextrin-maltose instead of ethanol. Chronic ethanol administration resulted in the increased amount of myocardial thiobarbituric acid reactive substances(TBARS), the parameter of lipid peroxidation, under our experimental condition. Chronic ethanol ingestion did not cause any change in activities of either glutathione peroxidase or glutathione reductase while it increased that of catalase. On the other hand, the activities of glutathione transferase and glucose-6-phosphate dehydrogenase were decreased after ethanol treatment. Therefore, chronic ethanol administration seemed to cause considerable changes in cellular defense function against oxidative tissue damage in rat myocardium through glutathione utilizing system and radical generation system. However the ultimate net result of chronic ethanol ingestion on the myocardium of rat was the oxidative tissue damage revealed by increased TBARS content.

목차 (Table of Contents)

• 요약문
• 도표목차
• Abstract
• 1.서론
• 2.연구대상 및 방법
• 3.연구결과
• 4.고찰
• 5.결론
• 6.참고문헌