Iron‐Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes

다국어 초록 (Multilingual Abstract)

Asymmetric aminoazidation and diazidation of alkenes are straightforward strategies to build value‐added chiral nitrogen‐containing compounds from feedstock chemicals. They provide direct access to chiral organoazides and complement enantioselective diamination. Despite the advances in non‐asymmetric reactions, asymmetric aminoazidation or diazidation based on acyclic systems has not been previously reported. Here we describe the iron‐catalyzed intermolecular asymmetric aminoazidation and diazidation of styrenes. The method is practically useful and requires relatively low loading of catalyst and chiral ligand. With mild reaction conditions, the reaction can be completed on a 20 mmol scale. Studies of the mechanism suggest that the reaction proceeds via a radical pathway and involves stereocontrol of an acyclic free radical which probably takes place through a group transfer mechanism.
Biologically accessible hydroxylation in nature often proceeds through a radical rebound process. However, such a radical rebound usually leads to non‐stereoselectivity. Rendering the radical rebound enantioselective is quite challenging. Herein, the first radical asymmetric aminoazidation and diazidation on acyclic systems via radical rebound is reported.