Regulation of Fumonisin Biosynthesis in Fusarium verticillioides-Maize System

다국어 초록 (Multilingual Abstract)

Fumonisins are a group of mycotoxins produced by a
pathogen Fusarium verticillioides in infected maize
kernels. Consumption of fumonisin-contaminated maize
has been implicated in a number of animal and human
illnesses, including esophageal cancer and neural tube
defects. Since the initial discovery, chemistry, toxicology,
and biology of fumonisins as well as the maize-
Fusarium pathosystem have been extensively studied.
Furthermore, in the past decade, significant progress
has been made in terms of understanding the molecular
biology of toxin biosynthetic genes. However, there is a
critical gap in our understanding of the regulatory
mechanisms involved in fumonisin biosynthesis. Here,
we review and discuss our current knowledge about the
molecular mechanisms by which fumonisin biosynthesis
is regulated in F. verticillioides. In addition, we discuss
the impact of maize kernel environment, particularly
sugar and lipid molecules, on fumonisin biosynthesis.

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