소아 비출혈의 한약 치료에 대한 임상 연구 동향 - 2000년대 이후 발표된 중국 RCT 연구를 중심으로 - = Review of Clinical Studies of Herbal Medicine Treatment for Pediatric Epistaxis – Focused on Chinese Randomized Controlled Trials after 2000s -

국문 초록 (Abstract)

목적: 이 연구의 목적은 중국에서 진행되고 있는 소아 비출혈의 한약치료의 효과에 대한 최근의 임상연구를 분석하여, 향후 국내에서 소아 비출혈에 대해 새로운 치료법의 개발 및 후행연구를 할 수 있는 기틀을 마련하기 위함이다.
방법: 중국 전자 데이터베이스 검색사이트인 중국학술정보원 (China National Knowledge Infrastructure, CNKI)을 이용하였으며, 검색어는 ‘鼻出血’, ‘鼻衄’, ‘衄血’, ‘中药’, ‘中医药’, ‘本草’, ‘汤’, ‘丸’, ‘散’, ‘方’,‘颗粒’, ‘胶囊’, ‘自拟’, ‘外用’, ‘膏’를 사용하여 2000년 1월에서 2019년 11월까지의 문헌을 검색하였다. 그 후 각 문헌에 나온 치료방법과 결과에 대해 검토하였다.
결과: 1141개의 연구 중, 12개의 RCT 연구가 선정되어 분석되었다. 대부분의 연구에서, 소아 비출혈에 대한 한약치료의 효과는 유의하게 높았으며, 내복약 중에 가장 많이 사용된 본초는 Rehmanniae Radix (生地黃), Scutellariae Radix (黄芩), Imperatae Rhizoma (白茅根) 이었다. 외용약으로 가장 많이 사용된 본초는 Notoginseng Radix (三七), Bletilla striata (白芨), Crinis Carbonisatus (血餘炭)이었다.
결론: 한약치료는 소아 비출혈을 치료하는데 도움이 될 수 있다는 결론을 얻었으며, 이를 뒷받침하기 위한 후행연구가 필요하다. 치료 경과를 정확히 파악할 수 있는 통일된 평가지표도 필요할 것으로 생각된다.

다국어 초록 (Multilingual Abstract)

Objectives: The purpose of this study is to investigate recent clinical studies on the effect of herbal medicine for pediatric epistaxis in China, and to seek better methods to treat and study for pediatric epistaxis in Republic of Korea.
Methods: We searched the clinical studies from the China Academic Journal (CAJ) in China National Knowledge Infrastructure (CNKI) by key words 鼻出血’, ‘鼻衄’, ‘衄血’, ‘中药’, ‘中医药’, ‘本草’, ‘汤’, ‘丸’, ‘散’, ‘方’,‘颗粒’, ‘胶囊’, ‘自拟’, ‘外用’, ‘膏 from January 2000 to November 2019. We analyzed the literature in regards to the treatment methods and results.
Results: Among the 1141 searched studies, 12 randomized controlled trials were selected and analyzed. In most of the studies, the effectiveness of herbal medicine on pediatric epistaxis was significantly high. The most commonly used herbs for oral administration were Rehmanniae Radix (生地黃), Scutellariae Radix (黄芩), Imperatae Rhizoma (白茅根). The most commonly used herbs for external applications were Notoginseng Radix (三七), Bletilla striata (白芨), Crinis Carbonisatus (血餘炭).
Conclusions: Herbal medicine treatment can help improve pediatric epistaxis. Additional studies need to be performed to solidify these findings. In addition to that, unified criteria for treatment of pediatric epistaxis should be established in Republic of Korea.

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