Growth and Development of Infants with Asymptomatic Congenital Cytomegalovirus Infection

다국어 초록 (Multilingual Abstract)

Purpose: To observe changes in audiology, intellectual development, behavior development, and physical growth
during systematic follow-up of infants with asymptomatic congenital human cytomegalovirus (HCMV) infection.
Materials and Methods: Fifty-two infants diagnosed with asymptomatic congenital HCMV infection from July
2003 to July 2007 served as the infection group, and 21 healthy infants served as the control group. All infants were
confirmed to have HCMV infection by Fluorescent Quantative polymerase chain reaction (FQ-PCR). In both the
infection and control groups, the neonates and infants at 3 months, 6 months, and 1 year of age underwent
examinations. Results: 1) 20 items of National Black Nurses Association (NBNA) scores of neonates 12-14 days
after birth in 2 groups were 38.3 ± 1.95 and 38.5 ± 2.29, without significant differences. 2) Auditory test: 50 ears of
25 cases in the infection group showed abnormal auditory thresholds in V waves with an abnormal rate of 14%,
while no abnormalities were found in 21 cases in the control group. 3) Mental and psychomotor development index
scores in the control group (107.49 ± 11.31 and 107.19 ± 10.98) were compared with those in 41 asymptomatically
infected infants at 1 year of age (107.21 ± 9.96 and 108.31 ± 11.25), and no statistically significant difference was
noted. Conclusion: 1) An elevated threshold in the V wave was present in asymptomatically infected infants, but
could not be detected through otoacoustic emission (OAE) screening. 2) Either in the neonatal or infant periods,
asymptomatic congenital HCMV infection did not have a significant influence on nervous behavior or on physical
and intellectual development.

다국어 초록 (Multilingual Abstract)

Purpose: To observe changes in audiology, intellectual development, behavior development, and physical growth
during systematic follow-up of infants with asymptomatic congenital human cytomegalovirus (HCMV) infection.
Materials and Methods: Fifty-two infants diagnosed with asymptomatic congenital HCMV infection from July
2003 to July 2007 served as the infection group, and 21 healthy infants served as the control group. All infants were
confirmed to have HCMV infection by Fluorescent Quantative polymerase chain reaction (FQ-PCR). In both the
infection and control groups, the neonates and infants at 3 months, 6 months, and 1 year of age underwent
examinations. Results: 1) 20 items of National Black Nurses Association (NBNA) scores of neonates 12-14 days
after birth in 2 groups were 38.3 ± 1.95 and 38.5 ± 2.29, without significant differences. 2) Auditory test: 50 ears of
25 cases in the infection group showed abnormal auditory thresholds in V waves with an abnormal rate of 14%,
while no abnormalities were found in 21 cases in the control group. 3) Mental and psychomotor development index
scores in the control group (107.49 ± 11.31 and 107.19 ± 10.98) were compared with those in 41 asymptomatically
infected infants at 1 year of age (107.21 ± 9.96 and 108.31 ± 11.25), and no statistically significant difference was
noted. Conclusion: 1) An elevated threshold in the V wave was present in asymptomatically infected infants, but
could not be detected through otoacoustic emission (OAE) screening. 2) Either in the neonatal or infant periods,
asymptomatic congenital HCMV infection did not have a significant influence on nervous behavior or on physical
and intellectual development.

참고문헌 (Reference)

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