Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation = Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation

다국어 초록 (Multilingual Abstract)

Estrogen receptor α (ER-α), which is involved in bone me-Tabolism and breast cancer, has been shown to have tran-scriptional targets. Dlx3 is essential for the skeletal devel-opment and plays an important role in osteoblast differen-tiation. Various osteogenic stimulators and transcription factors can induce the protein expression of Dlx3. Howev-er, the regulatory function of ER-α in the Dlx3 mediated osteogenic process remains unknown. Therefore, we in-vestigated the regulation of Dlx3 and found that ER-α is a positive regulator of Dlx3 transcription in BMP2-induced osteoblast differentiation. We also found that ER-α inter-acts with Dlx3 and increases its transcriptional activity and DNA binding affinity. Furthermore, we demonstrated that the regulation of Dlx3 activity by ER-α is independent of cate that Dlx3 is a novel target of ER-α, and that ER-α regu-lates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3.