Metabolic syndrome and risk of lung cancer : A analysis of Korean National Health Insurance Service database = Metabolic syndrome and risk of lung cancer : A analysis of Korean National Health Insurance Service database

다국어 초록 (Multilingual Abstract)

Objective: It has been known that metabolic syndrome is associated with increased risk of several cancers. However, the association between lung cancer and metabolic syndrome remains unclear. We investigated the impact of metabolic syndrome on lung cancer incidence.
Methods: Examinees of health screen by the Korean National Health Insurance between Jan 2009 and Dec 2012 were enrolled. Those with lung cancer diagnosis within 5 years before baseline were excluded. The incidence of lung cancer based on ICD-10 code was observed until Dec 2016. We analyzed the risk of lung cancer according to 1) presence of metabolic syndrome, 2) components of metabolic syndrome (fasting plasma glucose, abdominal obesity, triglycerides, high density lipoprotein, hypertension) and 3) number of components of metabolic syndrome.
Results: During the study period, 71,792 incidence of lung cancer was observed among 22,809,722 persons (3.14 per 1000 person year). The hazard ratio of metabolic syndrome and all of its components (except for hypertension in females) remained significant in a multivariate model adjusted for age, smoking status, body mass index, physical activity (HR of metabolic syndrome 1.16, 95% CI=1.145-1.181 in males, HR of metabolic syndrome 1.06 95% CI=1.032-1.085 in females). Furthermore, the risk of lung cancer increased with the number of components present. The association between metabolic syndrome and lung cancer was more obvious in males than female participants.
Conclusion: Metabolic syndrome is associated with increased risk of lung cancer incidence, especially in men.