정량적 갑상선 조직 탄성도 분석을 통한 전단파 탄성초음파의 갑상선암 진단 유용성에 관한 연구 연세대학교 = Diagnostic Performance of Quantitative Shear Wave Ultrasound Elastography for Thyroid Cancer

다국어 초록 (Multilingual Abstract)

Background and Objectives: Thyroid ultrasonography (US) is a useful diagnostic tool for the evaluation of thyroid cancer. And US elastography is a newly developed dynamic technique that can provide an estimation of thyroid nodule stiffness. The aim of this study was to evaluate the role of conventional US and shear wave elastography in the diagnosis of thyroid cancer. Materials and Methods: Eighty one patients who underwent both conventional US and shear wave elastography were included in this study. Patients were classified into benign and malignant groups according to the cytopathologic results. We evaluated and compared the diagnostic performances of conventional US, shear wave elastography, and combination of conventional US with shear wave elastography. Results: Of 81 nodules, 58 were benign and 23 were malignant. All diagnostic performances of conventional US were higher than those of shear wave elastography. The area under the receiver operating characteristic curve (Az) of conventional US was superior (Az=0.792) to that of shear wave elastography (Az=0.609) (p=0.049) and that of combination of conventional US with shear wave elastography (Az=0.72) (p=0.118). Conclusion: Conventional US was good diagnostic modality for diagnosing thyroid cancer.
Shear wave elastography itself or a combination of conventional US with shear wave elastography was not as useful as the use of conventional US alone for predicting thyroid malignancy

참고문헌 (Reference)

1 김기황, "갑상선 우연종의 발견과 대처 방안" 대한초음파의학회 27 (27): 111-117, 2008

2 Yang GC, "Ultrasound-guided fine-needle aspiration of the thyroid assessed by Ultrafast Papanicolaou stain: data from 1135 biopsies with a two- to six-year follow-up" 11 (11): 581-589, 2001

3 Carmeci C, "Ultrasound-guided fine-needle aspiration biopsy of thyroid masses" 8 (8): 283-289, 1998

4 Cai XJ, "Ultrasound-guided fine needle aspiration cytology in the diagnosis and management of thyroid nodules" 17 (17): 251-256, 2006

5 Peccin S, "Ultrasonography: is it useful in the diagnosis of cancer in thyroid nodules?" 25 (25): 39-43, 2002

6 Asteria C, "US-elastography in the differential diagnosis of benign and malignant thyroid nodules" 18 (18): 523-531, 2008

7 Takashima S, "Thyroid nodules: clinical effect of ultrasound-guided fine-needle aspiration biopsy" 22 (22): 535-542, 1994

8 Tan GH, "Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging" 126 (126): 226-231, 1997

9 Khoo ML, "Thyroid calcification and its association with thyroid carcinoma" 24 (24): 651-655, 2002

10 Ogawa Y, "The value of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: an assessment of its diagnostic potential and pitfalls" 31 (31): 97-101, 2001

11 Cappelli C, "The predictive value of ultrasound findings in the management of thyroid nodules" 100 (100): 29-35, 2007

12 Lee YH, "Sonographically guided fine needle aspiration of thyroid nodule: discrepancies between cytologic and histopathologic findings" 36 (36): 6-11, 2008

13 Sebag F, "Shear wave elastography: a new ultrasound imaging mode for the differential diagnosis of benign and malignant thyroid nodules" 95 (95): 5281-5288, 2010

14 Moon HG, "Role of ultrasonography in predicting malignancy in patients with thyroid nodules" 31 (31): 1410-1416, 2007

15 Papini E, "Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features" 87 (87): 1941-1946, 2002

16 Shiina T, "Real-time tissue elasticity imaging using the combined autocorrelation method" 2007 : 4-7, 2007

17 Kang HW, "Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas" 14 (14): 29-33, 2004

18 Kim EK, "New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid" 178 (178): 687-691, 2002

19 Frates MC, "Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement" 237 (237): 794-800, 2005

20 Cooper DS, "Management guidelines for patients with thyroid nodules and differentiated thyroid cancer" 16 (16): 109-142, 2006

21 Cappelli C, "Is the anteroposterior and transverse diameter ratio of nonpalpable thyroid nodules a sonographic criteria for recommending fine-needle aspiration cytology?" 63 (63): 689-693, 2005

22 Park SH, "Interobserver agreement in assessing the sonographic and elastographic features of malignant thyroid nodules" 193 (193): W416-W423, 2009

23 Mortensen JD, "Gross and microscopic findings in clinically normal thyroid glands" 15 (15): 1270-1280, 1995

24 Ylagan LR, "Fine needle aspiration of the thyroid: a cytohistologic correlation and study of discrepant cases" 14 (14): 35-41, 2004

25 Sangalli G, "Fine needle aspiration cytology of the thyroid: a comparison of 5469 cytological and final histological diagnoses" 17 (17): 245-250, 2006

26 Rago T, "Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules" 92 (92): 2917-2922, 2007

27 Tae HJ, "Diagnostic value of ultrasonography to distinguish between benign and malignant lesions in the management of thyroid nodules" 17 (17): 461-466, 2007

28 Danese D, "Diagnostic accuracy of conventional versus sonography-guided fine-needle aspiration biopsy of thyroid nodules" 8 (8): 15-21, 1998

29 Chan BK, "Common and uncommon sonographic features of papillary thyroid carcinoma" 22 (22): 1083-1090, 2003

30 Cho BY, "Clinical thyroidology" Korea Medical Book 2005

31 Hegedus L, "Clinical practice. The thyroid nodule" 351 (351): 1764-1771, 2004

32 Frates MC, "Can color Doppler sonography aid in the prediction of malignancy of thyroid nodules?" 22 (22): 127-134, 2003

33 Athanasiou A, "Breast lesions: quantitative elastography with supersonic shear imaging--preliminary results" 256 (256): 297-303, 2010

34 Bukhari MH, "An updated audit of fine needle aspiration cytology procedure of solitary thyroid nodule" 36 (36): 104-112, 2008

35 Friedrich-Rust M, "Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility study" 52 (52): 69-74,