수종 항원이 Mouse의 이물성 육아종에 미치는 조직학적 영향 = A Study on the Histopathological Effect of Antigens upon the Foreign-Body Granuloma in Swiss Mouse

국문 초록 (Abstract)

Swiss mice의 복벽에 silicon주사로 foreign-body granuloma를 야기시켜, 항원을 주 2회 1개월과 2개월 동안 주사하여 異物주변의 조직반응을 검사하였다. 조직반응은 1개원군은 대조군보다, 2개월군은 1개월군보다 良好한 반응을 보여 주었다.

다국어 초록 (Multilingual Abstract)

An experimental model to evaluate the non-specific immune response was designed by examining the stromal reaction, namely, inflammatory cell infiltration and fibrous proliferation, around a silicon-induced foreign-body in the Swiss mous.
The mice were injected subcutaneously with silicon into the abdominal wall and produced a foreign-body granuloma.
Next, the mice were treated with non-specific antigens(DT, PPD and Maruyama vaccine) biweekly for one month and two months.
The following results were obtained;
1.Non-specific antigen administration had brought a better stromal reaction, namely, lymphocytic and monocytic infiltration and fibrosis around the foreign body. The change is more marked in the two months' groups.
2.There was no notable difference on the stromal reaction regardless the difference of the vaccines.
3.There was no peripheral leukocytosis nor increased number of lymphocytes in the must experimental groups.

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.방법 및 재료
• Ⅲ.성적
• Ⅳ.고찰
• Ⅴ.결론