응급실에서 급성 췌장염 환자의 선별을 위한 actim Pancreatitis 검사의 유용성 = Usefulness of actim Pancreatitis(R) Test for Screening of Acute Pancreatitis in The ED

다국어 초록 (Multilingual Abstract)

Background: Acute pancreatitis is a fairly common abdominal disorder that can be easily confronted in the emergency department (ED) and is one of the most complex and clinically challenging of all abdominal disorders. Currently, there is no gold standard for the diagnosis of acute pancreatitis. We evaluated the usefulness of the actim PancreatitisR rapid test, which has been recently developed in Europe, as a screening test of acute pancreatitis in our emergency department. Methods: We prospectively studied the urinary trypsinogen-2 dipstick tests (actim PancreatitisR , Medix Biochemica, Kauniainen, Finland) of 200 patients with acute abdominal pain who were treated at our ED. All urine samples were collected from the patients within 12 hours of arrival at ED. We also measured serum amylase assay in the laboratory and compared the sensitivities and the specificities of the two test. Acute pancreatitis was diagnosed by authors according to standardized criteria. Abdominal USG or CT was performed when a patient with a normal serum amylase level had a typical clinical presentation. Results: The actim PancreatitisR rapid test was positive in 22 of the 25 patients with acute pancreatitis (sensitivity, 88.0 percent). The test was also positive in 6 of 175 patients without pancreatitis (specificity, 96.6 percent). The serum amylase assay had a sensitivity of 68.0 percent (with a cutoff value of 300 U per liter for the upper reference limit) and a specificity of 90.9 percent. But there were no statistical differences between the correlation coefficients of the two tests as diagnostic tool. Conclusion: In patients with acute abdominal pain who are seen in the emergency department, the actim PancreatitisR urinary dipstick test has a high degree of probability as a screening test for acute pancreatitis. Also it can easily and rapidly be use at the bedside.