Roles of Plant Proteases in Pathogen Defense

다국어 초록 (Multilingual Abstract)

The genomes of plants contain more than 600 genes
encoding a diverse set of proteases and the subunits of
proteasomes. These proteases and proteasomes consist
of plant proteolytic systems, which are involved in
various cellular metabolic processes. Plant proteolytic
systems have been shown to have diverse roles in
defense responses, such as execution of the attack on the
invading organisms, participation in signaling cascades,
and perception of the invaders. In order to provide a
framework for illustrating the importance of proteolytic
systems in plant defense, characteristics of non-proteasome
proteases and the 26S proteasome are summarized.
The involvement of caspase-like proteases, saspases,
apoplastic proteases, and the 26S proteasome in pathogen
defense suggests that plant proteolytic systems are
essential for defense and further clarity on the roles of
plant proteases in defense is challenging but fundamentally
important to understand plant-microbe interactions.

참고문헌 (Reference)

1 Bonneau, L., "What happened to plant caspases?" 59 : 491-499, 2008

2 Navarre, D. A., "Victorin induction of an apoptotic, senescence-like response in oats" 11 : 237-250, 1999

3 Kuroyanagi, M., "Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana" 280 : 32914-32920, 2005

4 Sanchez-Serrano, J. J., "VPEg exhibits a caspase-like activity that contributes to defense against pathogens. Curr. Biol. 14:1897-1906. Sanmartin, M., Jaroszewski, L., Raikhel, N. V. and Rojo, E. 2005. Caspases. Regulating death since the origin of life" 137 : 841-847, 2005

5 Rojo, E., "VPEg exhibits a caspase-like activity that contributes to defense against pathogens" 14 : 1897-1906, 2004

6 Dreher, K. A., "Ubiquitin, hormones and biotic stress in plants." 9 : 787-822, 2007

7 Watanabe, N., "Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast" 280 : 14691-14699, 2005

8 Glickman, M. H., "The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol" 82 : 373-428, 2002

9 Small, J., "The ubiquitin 26S proteasome proteolytic pathway." 55 : 555-590, 2004

10 van der Hoorn, R. A. L., "The plant proteolytic machinery and its role in defence." 7 : 400-407, 2004

11 Jones, J. D. G., "The plant immune system." 444 : 323-329, 2006

12 Roberts, K., "The plant extracellular matrix: in a new expansive mood." 6 : 688-694, 1994

13 Liu, Y., "The matrix metalloproteinase gene GmMMP2 is activated in response to pathogenic infections in soybean" 127 : 1788-1797, 2001

14 Combier, J. P., "The MtMMPL1 early nodulin is a novel member of the matrix metalloendoproteinase family with a role in Medicago truncatula infection by Sinorhizobium meliloti" 144 : 703-716, 2007

15 Kurepa, J., "Structure, function and regulation of plant proteasomes." 90 : 324-335, 2008

16 McGeehan, G., "Sequencing and characterization of the soybean leaf metalloproteinase: Structural and functional similarity to the matrix metalloproteinase family." 99 : 1179-1183, 1992

17 van Doorn W. G., "Senescence and programmed cell death: substance or semantics?" 55 : 2147-2153, 2004

18 Devoto, A., "Role of ubiquitination in the regulation of plant defence against pathogens" 6 : 307-311, 2003

19 Hao, L., "Role of two cysteine proteinases in the susceptible response of Nicotiana benthamiana to Colletotrichum destructivum and the hypersensitive response to Pseudomonas syringae pv" 170 : 1001-1009, 2006

20 El Moussaoui A., "Revisiting the enzymes stored in the laticifers of Carica papaya in the context of their possible participation in the plant defence mechanism" 58 : 556-570, 2001

21 Watanabe, N., "Recent advance in the study of caspase-like protease and Bax inhibitor-1 in plants: their possible roles as regulators of programmed cell death" 5 : 65-70, 2004

22 Graham, I. A., "Purification and developmental analysis of a metalloproteinase from the leaves of Glycine max" 97 : 786-792, 1991

23 Coffeen, W. C., "Purification and characterization of serine proteases that exhibit caspase-like activity and are associated with programmed cell death in Avena sativa" 16 : 857-873, 2004

24 Ellis, C., "Protein complexes mediate signalling in plant responses to hormones, light, sucrose and pathogens" 50 : 971-980, 2002

25 Lequeu, J., "Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions" 579 : 4879-4886, 2005

26 Garcia-Lorenzo, M., "Protease gene families in Populus and Arabidopsis." 6 : 30-, 2006

27 Suty, L., "Preferential induction of 20S proteasome subunits during elicitation of plant defense reactions: towards the characterization of plant defense proteasomes" 35 : 637-650, 2003

28 Avrova, A. O., "Potato oxysterol binding protein and cathepsin B are rapidly up-regulated in independent defence pathways that distinguish R gene-mediated and field resistances to Phytophthora infestans" 5 : 45-56, 2004

29 Beers, E. P., "Plant proteolytic enzymes: possible roles during programmed cell death" 44 : 399-415, 2000

30 van der Hoorn, R. A. L., "Plant proteases: From pheotypes to molecular mechanisms." 59 : 191-223, 2008

31 Agrios, G. N., "Plant Pathology, 5th Ed." Elservier Academic Press 2005

32 Shindo, T., "Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders" 9 : 119-125, 2008

33 Golldack, D., "Mutation of the matrix metalloproteinase At2-MMP inhibits growth and causes late flowering and early senescence in Arabidopsis." 5541-5547, 2007

34 Li, Z., "Molecular cloning and sequence analysis of a cDNA encoding a cysteine proteinase inhibitor from sorghum bicolor seedlings" 251 : 499-502, 1996

35 He, R., "Metacaspase-8 modulates programmed cell death induced by UV and H2O2 in Arabidopsis" 283 : 774-783, 2007

36 Nagase, H., "Matrix metalloproteinases." 274 : 21491-21494, 1999

37 Maidment, J. M., "Matrix metalloproteinase homologues from Arabidopsis thaliana." 274 : 34706-34710, 1999

38 Rawlings, N. D., "MEROPS: the peptidase database." 34 : D270-272, 2006

39 Rawlings, N. D., "MEROPS: the peptidase database." 27 : 325-331, 1999

40 Li, J., "Kunitz Trypsin Inhibitor: An antagonist of cell death triggered by phytopathogens and fumonisin B1 in Arabidopsis" 1 : 482-495, 2008

41 Gilroy, E. M, "Involvement of cathepsin B in the plant disease resistance hypersensitive response" 52 : 1-13, 2007

42 Becker, J., "Induction of competence for elicitation of defense responses in cucumber hypocotyls requires proteasome activity" 21 : 311-, 2000

43 Uren, A. G., "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma" 6 : 961-967, 2000

44 Van Baarlen, P., "Histochemical and genetic analysis of host and non-host interactions of Arabidopsis with three Botrytis species: an important role for cell death control" 8 : 41-54, 2007

45 Barrett, A. J., "Handbook of Proteolytic Enzymes." Elservier Academic Press 2004

46 Kraft, E., "Genome analysis and functional characterization of the E2 and ring domain E3 ligase ubiquitination enzymes of Arabidopsis thaliana" 139 : 1597-1611, 2005

47 Shabab, M., "Fungal effector protein AVR2 targets diversifying defenserelated Cys proteases of tomato.Plant Cell 20:1169-1183" 20 : 1169-1183, 2008

48 Jesenberger, V., "Deadly encounter: ubiquitin meets apoptosis." 3 : 112-121, 2002

49 Dahan, J., "Cryptogein affects expression of α3, α6 and b1 20S proteasome subunits encoding genes in tobacco" 52 : 1947-1948, 2001

50 Pak, J. H., "Construction and characterization of the soybean leaf metalloproteinase cDNA" 404 : 283-288, 1997

51 Petitot, A. S., "Cloning of two plant cDNAs encoding a beta-type proteasome subunit and a transformer-2-like SR-related protein: early induction of the corresponding genes in tobacco cells treated with cryptogein" 35 : 261-269, 1997

52 Luderer, R., "Cladosporium fulvum overcomes Cf-2-mediated resistance by producing truncated AVR2 elicitor proteins" 45 : 875-884, 2002

53 Rooney, H. C., "Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance" 308 : 1783-1786, 2005

54 Simoes, I., "Characterization of recombinant CDR1, an Arabidopsis aspartic proteinase involved in disease resistance" 282 : 31358-31365, 2007

55 Grutter, M. G., "Caspases: key players in programmed cell death." 10 : 649-655, 2000

56 Delaure, S., "Building up plant defense by breaking down proteins." 174 : 375-385, 2008

57 Buchanan, B. B., "Biochemistry and Molecular Biology of Plants. American Society of Plant Physiologists" Rockville 447-, 2002

58 Xia, Y., "An extracellular aspartic protease functions in Arabidopsis disease resistance signaling" 23 : 980-988, 2004

59 Hoeberichts, F. A., "A tomato metacaspase gene is upregulated during programmed cell death in Botrytis cinerea-infected leaves" 217 : 517-522, 2003

60 Kruger, J., "A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis" 296 : 744-747, 2002

61 Hatsugai, N., "A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death" 305 : 855-858, 2004

62 Groll, M., "A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism" 452 : 755-758, 2008

63 Lee, S. J., "A functional screen to characterize the secretomes of eukaryotic pathogens and their hosts in planta" 19 : 1368-1377, 2006

64 Avrova, A. O., "A cysteine protease gene is expressed early in resistant potato interactions with Phytophthora infestans" 12 : 1114-1119, 1999

65 Belenghi, B., "A cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death" 270 : 2593-2604, 2003

66 Madeo, F., "A caspase-related protease regulates apoptosis in yeast." 9 : 911-917, 2002

67 Tian, M., "A Phytophthora infestans cystatin-like protein targets a novel tomato papain-like apoplastic protease" 143 : 364-377, 2007

68 Tian, M., "A Kazal-like extracellular serine protease inhibitor from Phytophthora infestans targets the tomato Pathogenesisrelated Protease P69B" 279 : 26370-26377, 2004