再生不良性貧血의 臨床血液學的觀察 = CLINICAL AND HEMATOLOGICAL OBSERVATIONS ON APLASTIC ANEMIA

다국어 초록 (Multilingual Abstract)

⑴ The author presented 26 cases of aplastic anemia which were seen at Kyung-Pook University Hospital in period between April 1958 and August 1960.
⑵ Chemical exposure was assumed to be the etiological agents in nine cases, while the cause was unknown in 17.
⑶ The most common presenting symptom was general weakness (88%). The liver was palpable in 27% and the spleen was felt in 8% of the patients.
⑷ All cases had severe pancytopenia and in 23 of them, relative lymphocytosis was present.
⑸ In all 26 cases, coagulation studies were carried out. Of 26 casee, 24 showed positive Rumpel Leede test. Prolonged bleeding time and recalcification time were observed in all cases.
⑹ Bone marrow aspirations were performed in all 26 cases, and detailed morphological studies were done. Of 26 cases, 15 disclosed acellular marrow, 4 hypocellular marrow, 2 normocellular marrow and the remaining 5 cases hypercellular marrow. In the hypercellular marrow, myeloid maturation arrest and degeneration of megakaryocytes were found.
⑺ In all cases, Coomb's tests were performed out of which only one was positive. Platelet agglutination tests were negative in all 26 cases. Leukoagglutins were present in 4 of them.
⑻ Bone marrow function studies with chlorophyll-cobalt were done in 10 cases and revealed values less than the normal range in all 10 of them.
⑼ The pertinent liver function studies revealed abnormal findings in 5 of 9 cases examined.
⑽ The serum iron levels were above the normal in all 15 cases determined, and also hemosiderin on the bone marrow smears were increased in 4 of ll cases examined.
⑾ Cytochemical studies including keukocyte alkaline phosphatase, leukocyte glycogen and megakaryocytic glycogen were done and the significance of their findings was discussed.
⑿ Of 26 cases, 15 were dead, 3 were missing and the remainder were under the treatment, as of August 1960.
⒀ As therapeutic methods, hemostatic agents, repeated blood transfusions, folic acid, vitamin B_12, steroids, testosterone and bone marrow transplantions were employed. Of them, folic acid and vitamin B_12 were ineffective.
⒁ Testosterone were administered to 6 cases and 2 of them showed remarkable effects.
⒂ Bone marrow transplantations were performed in 3 cases. In the first case, 6.26×10 exp(9) uncleated cells were infused intravenously, and in the remaining 2 cases, 1×10 exp(9) uncleated cells were given respectively. In one case, transient reticulocytosis and maintenance of the pretreatment hemoglobin level were observed for one month and in another case, mild reticulocytosis was maintained for four months, However, the remaining one case showed no response.