Preparative Method of R-(？)-Ibuprofen by Diastereomer Crystallization

다국어 초록 (Multilingual Abstract)

The economic and effective method for preparation of R-(-)-ibuprofen by diastereomer crystallization
was developed. R-(-)-ibuprofen was resolved from racemic ibuprofen by forming R-(-)-
ibuprofen-R-(+)-α-methylbenzylamine diastereomeric salt with R-(+)-α-methylbenzylamine and
crystallization. The purity of R-(-)-ibuprofen-R-(+)-α-methylbenzylamine diastereomeric salt
was tested and confirmed using HPLC and 1H-NMR method. The pure diastereomeric salt collected
from repeated recrystallization was further fractionated by liquid-liquid extraction to the
pure enantiomer without racemization. R-(-)-ibuprofen was recovered producing overall yield of
2.4% with the purity more than 99.97%.

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