악성림프종에서 SV40 Large T Antigen의 검색 = Detection of SV40 Large T Antigen in Malignant Lymphomas

다국어 초록 (Multilingual Abstract)

Background : The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant
lymphomas among Korean patients. Methods : One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochemical staining for SV40 large T antigen (TAg), using an extremely sensitive, tyramide based, catalyzed signal amplification method. Results : From 158 non-Hodgkin’s lymphomas, including 115 diffuse large B-cell lymphomas,
and 15 Hodgkin’s lymphomas, none of the cases were positive for SV40 TAg. Conclusions : SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans.

다국어 초록 (Multilingual Abstract)

Background : The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant
lymphomas among Korean patients. Methods : One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochemical staining for SV40 large T antigen (TAg), using an extremely sensitive, tyramide based, catalyzed signal amplification method. Results : From 158 non-Hodgkin’s lymphomas, including 115 diffuse large B-cell lymphomas,
and 15 Hodgkin’s lymphomas, none of the cases were positive for SV40 TAg. Conclusions : SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans.

참고문헌 (Reference)

1 Heinsohn S, "Standardized detection of Simian virus 40 by real-time quantitative polymerase chain reaction in pediatric malignancies" 90 : 94-99, 2005

2 Vilchez RA, "Standardized detection of SV40 by real time quantitative polymerase chain re" 90 : 6-, 2005

3 Martini F, "Simian-virus-40 footprints in human lymphoproliferative disorders of HIV- and HIV+ patients" 78 : 669-674, 1998

4 Vivaldi A, "Simian virus 40-like sequences from early and late regions in human thyroid tumors of different histotypes" 88 : 892-899, 2003

5 Vilchez RA, "Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDSrelated non-Hodgkin’s lymphoma" 342 : 38-46, 2005

6 Nakatsuka S, "Simian virus 40 sequences in malignant lymphomas in Japan" 63 : 7606-7608, 2003

7 Barbanti-Brodano G, "Simian virus 40 infection in humans and association with human diseases: results and hypotheses" 318 : 1-9, 2004

8 Vilchez RA, "Simian virus 40 in human cancers" 114 : 675-684, 2003

9 Gluzman Y, "SV40-transformed simian cells support the replication of early SV40 mutants" 23 : 175-182, 1981

10 Shah KV, "SV40 and human cancer: a review of recent data" 120 : 215-223, 2007

11 Lee HS, "Protein expression profiling and molecular classification of gastric cancer by the tissue array method" 13 : 4154-4163, 2007

12 Shivapurkar N, "Presence of simian virus 40 DNA sequences in human lymphomas" 359 : 851-852, 2002

13 Amara K, "Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes" 121 : 2693-2702, 2007

14 Jaffe E, "Pathology and genetics of tumours of haematopoietic and lymphoid tissues" IARC 2001

15 Vilchez RA, "Novoa-Takara L, Chang CC. Simian virus 40 in posttransplant lymphoproliferative disorders" 37 : 1130-1136, 2006

16 Jin M, "Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan" 74 : 668-676, 2004

17 Brousset P, "Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non-Hodgkin’s lymphoma" 112 : 533-535, 2004

18 Stratton K, "Immunization safety review:SV40 contamination of polio vaccine and cancer" National Academy Press 2003

19 Doerries K, "Human polyomavirus JC and BK persistent infection" 577 : 102-116, 2006

20 Paik JH, "Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal centre and non-germinal centre B-like diffuse large Bcell lymphomas" 47 : 281-291, 2005

21 Chang MS, "Epstein-Barr virus and microsatellite instability in gastric carcinogenesis" 199 : 447-452, 2003

22 Numa F, "Elevated levels of syndecan-1 expression confer potent serum-dependent growth in human 293T cells" 55 : 4676-4680, 1995

23 Vilchez RA, "Association between simian virus 40 and non-Hodgkin lymphoma" 359 : 817-823, 2002

24 MacKenzie J, "Association between simian virus 40 DNA and lymphoma in the United Kingdom" 95 : 1001-1003, 2003

25 Fraumeni JF Jr, "An evaluation of the carcinogenicity of simian virus 40 in man" 185 : 713-718, 1963

26 O’Neill FJ, "Amplification of papovavirus defectives during serial low multiplicity infections" 112 : 800-803, 1981

27 Sui LF, "Absence of simian virus 40 (SV40) DNA in lymphoma samples from Tasmania, Australia" 37 : 157-159, 2005