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      KCI등재 SCOPUS

      에를로티닙과 라파티닙을 사용한 환자에서 발생한 표층점상각막병증 = Superficial Punctate Keratoepitheliopathy Under Treatment with Erlotinib and Lapatinib

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      https://www.riss.kr/link?id=A100533508

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      다국어 초록 (Multilingual Abstract)

      Purpose: To report the corneal superficial punctate keratoepitheliopathy in 2 patients taking the epidermal growth factor receptor (EGFR) inhibitors, erlotinib and lapatinib, respectively. Case summary: Case 1, who received erlotinib, showed trichomeg...

      Purpose: To report the corneal superficial punctate keratoepitheliopathy in 2 patients taking the epidermal growth factor receptor (EGFR) inhibitors, erlotinib and lapatinib, respectively. Case summary: Case 1, who received erlotinib, showed trichomegaly without touching the cornea and diffuse punctate keratoepitheliopathy. Corneal epitheliopathy and the corresponding symptoms resolved after discontinuation of the drug then recurred with reapplication. Case 2 presented diffuse corneal punctate epithelial erosions that developed without any cilia involvement after the patient was administered lapatinib. The visual acuity of both patients was not severely diminished and keratoepitheliopathy was mostly resolved with the treatment of preservative-free artificial tears and autologous serum eye drops. Conclusions: Erlotinib and lapatinib are both likely to cause visually tolerable corneal punctate keratoepitheliopathy which can be resolved with appropriate topical treatment. J Korean Ophthalmol Soc 2014;55(2):293-297

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      참고문헌 (Reference)

      1 Bouché O, "Trichomegaly of the eyelashes following treatment with cetuximab" 16 : 1711-1712, 2005

      2 Papadopoulos R, "Trichomegaly induced by erlotinib" 27 : 329-330, 2008

      3 Tsubota K, "Treatment of dry eye by autologous serum application in Sjögren's syndrome" 83 : 390-395, 1999

      4 Lyu J, "Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells" 12 : 1403-1410, 2006

      5 Ricciardi S, "Toxicity of targeted therapy in non-small-cell lung cancer management" 10 : 28-35, 2009

      6 Förster CG, "Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment" 105 : 269-273, 2008

      7 Nakamura Y, "The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis" 72 : 511-517, 2001

      8 Li T, "Skin toxicities associated with epidermal growth factor receptor inhibitors" 4 : 107-119, 2009

      9 Xu KP, "Role of ErbB2 in corneal epithelial wound healing" 45 : 4277-4283, 2004

      10 Foerster CG, "Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody)" 27 : 612-614, 2008

      1 Bouché O, "Trichomegaly of the eyelashes following treatment with cetuximab" 16 : 1711-1712, 2005

      2 Papadopoulos R, "Trichomegaly induced by erlotinib" 27 : 329-330, 2008

      3 Tsubota K, "Treatment of dry eye by autologous serum application in Sjögren's syndrome" 83 : 390-395, 1999

      4 Lyu J, "Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells" 12 : 1403-1410, 2006

      5 Ricciardi S, "Toxicity of targeted therapy in non-small-cell lung cancer management" 10 : 28-35, 2009

      6 Förster CG, "Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment" 105 : 269-273, 2008

      7 Nakamura Y, "The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis" 72 : 511-517, 2001

      8 Li T, "Skin toxicities associated with epidermal growth factor receptor inhibitors" 4 : 107-119, 2009

      9 Xu KP, "Role of ErbB2 in corneal epithelial wound healing" 45 : 4277-4283, 2004

      10 Foerster CG, "Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody)" 27 : 612-614, 2008

      11 Johnson KS, "Persistent corneal epithelial defect associated with erlotinib treatment" 28 : 706-707, 2009

      12 Frankfort BJ, "Periocular cutaneous toxicity and cicatricial ectropion: a potential class effect of antineoplastic agents that inhibit EGFR signaling" 23 : 496-497, 2007

      13 Tullo AB, "Ocular findings in patients with solid tumours treated with the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Phase I and II clinical trials" 19 : 729-738, 2005

      14 Methvin AB, "Newly recognized ocular side effects of erlotinib" 23 : 63-65, 2007

      15 Modjtahedi H, "Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities" 20 : 851-855, 2009

      16 Peréz-Soler R, "Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?" 23 : 5235-5246, 2005

      17 Garibaldi DC, "Cicatricial ectropion associated with treatment of metastatic colorectal cancer with cetuximab" 23 : 62-63, 2007

      18 Kojima T, "Autologous serum eye drops for the treatment of dry eye diseases" 27 (27): S25-S30, 2008

      19 Matsumoto Y, "Autologous serum application in the treatment of neurotrophic keratopathy" 111 : 1115-1120, 2004

      20 Flynn JF, "Anti-EGFR therapy: mechanism and advances in clinical efficacy in breast cancer" 2009 : 526963-, 2009

      21 Zhang G, "Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature" 26 : 858-860, 2007

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.22 0.22 0.22
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.23 0.366 0.02
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