<P>Reactive oxygen species (ROS) accumulation induces oxidative stress and cell damage, which then activates several signaling pathways and triggers inflammatory response. Biliverdin is a natural product of heme metabolism which is converted to ...
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https://www.riss.kr/link?id=A107473852
Kim, H.R. ; Kim, D.W. ; Jo, H.S. ; Cho, S.B. ; Park, J.H. ; Lee, C.H. ; Choi, Y.J. ; Yeo, E.J. ; Park, S.Y. ; Kim, S.T. ; Yu, Y.H. ; Kim, D.S. ; Kim, H.A. ; Cho, S.W. ; Han, K.H. ; Park, J. ; Eum, W.S. ; Choi, S.Y.
2015
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Cytokine ; Inflammation ; MAPK ; ROS ; Tat-BLVRA ; Protein therapy
SCOPUS,SCIE
학술저널
355-366(12쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Reactive oxygen species (ROS) accumulation induces oxidative stress and cell damage, which then activates several signaling pathways and triggers inflammatory response. Biliverdin is a natural product of heme metabolism which is converted to ...
<P>Reactive oxygen species (ROS) accumulation induces oxidative stress and cell damage, which then activates several signaling pathways and triggers inflammatory response. Biliverdin is a natural product of heme metabolism which is converted to bilirubin by the enzyme biliverdin reductase A (BLVRA) which also plays a role in antioxidant activity via the ROS scavenging activity of bilirubin. In this study, we examined the anti-inflammatory and anti-apoptotic effects of Tat-BLVRA protein on lipopolysaccharide (LPS)-induced inflammation in Raw 264.7 macrophage cells. Transduction of Tat-BLVRA protein into Raw 264.7 cells and mice ear tissue was tested by Western blot analysis and immunohistochemical analysis. Tat-BLVRA protein was effective in inhibiting mitogen activated protein kinases (MAPKs), Akt and NF-kappa B activation, intracellular ROS production and DNA fragmentation. Also, Tat-BLVRA protein significantly inhibited the expression of cytokines, COX-2, and iNOS. In a 12-O-tetradecanoylphobol 13-acetate (TPA)-induced mouse model, mice ears treated with Tat-BLVRA protein showed decreased ear thickness and weight, as well as inhibited MAPKs activation and cytokine expression. Thus we suggested that Tat-BLVRA protein may provide an effective therapeutic agent for inflammatory skin diseases. (C) 2014 Elsevier Ltd. All rights reserved.</P>
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