The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

다국어 초록 (Multilingual Abstract)

The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and todeclare the cut-off value of low muscle mass in an elderly Korean population. This studywas based on data from the 2008-2010 Korea National Health and Nutritional ExaminationSurveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bonemineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dualenergy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted byheight as a marker of sarcopenia. After confirming the correlation between low musclemass and BMD, the best cut-off value of muscle mass to estimate osteoporosis wassuggested through the receiver operating characteristic (ROC) curve. For both men andwomen, BMD correlated positively with low muscle mass when ASM/Ht2 was used as amarker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker forosteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. Whenthese cut-off values were used to determine sarcopenia, the risk of osteoporosis increased4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopeniawere more greatly affected than women (OR 1.15), even after adjusting for osteoporosisrisk factors. In elderly Korean people, sarcopenia is positively correlated with BMD andthere is a strong correlation between sarcopenia and osteoporosis with risk of bonefracture.

참고문헌 (Reference)

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