Synthesis of biodegradable polyurethanes and their applications for drug delivery and tissue engineering = 생분해성 폴리우레탄의 합성과 약물전달 및 조직공학적 응용

다국어 초록 (Multilingual Abstract)

In the engineering of cartilage tissues, scaffolds must have high elasticity and strength. And controllable biodegradable properties are necessary. We used biodegradable polyurethane as a scaffold material to meet this requirement. Four biodegradable PUs (PU12, PU13, PU14, PU15) were synthesized by different reaction molar ratios of polycaprolactone diol(PCL-diol) and MDI(4,4′-methylenediphenyl diisocyanate) to select the most suitable combination for cartilage regeneration. The synthesized PUs was analyzed by FT-IR, GPC, DSC and UTM. And degradation test was conducted to confirm the biodegradable properties. And the release behavior of four kinds of PU microspheres containing dexamethasone(DEX) was confirmed. The results of FT-IR, GPC, UTM and DSC data, degradation test and DEX release showed that PU12 is most suitable polymer. Therefore, we used PU12 to make microsphere containing kartojenin(KGN), a effective drug for cartilage regeneration, and the KGN release behavior examined. And then, the PU microspheres were packed and heated in an oven to connect the particles to each other to prepare a scaffold. The fabricated scaffold was observed through SEM and confirmed that the pore size had a size of 150 micrometers to 300 micrometers. The cell proliferation was conducted by seeding chondrocyte on the prepared scaffold. The number of cells increases with time. This biodegradable PU scaffold demonstrates potential for drug delivery systems and cartilage tissue engineering applications.

목차 (Table of Contents)

• Ⅰ. Abstract ·······················································5
• Ⅱ. Introduction ···················································7
• Ⅲ. Materials and Methods ········································11
• Ⅳ. Results and discussion ········································18
• Ⅴ. Conclusion ···················································25
• Ⅵ. References ···················································26