Melanin Inhibitory Activity and Skin Protection Effect of Artemisia scoparia in B16F10 Melanoma Cells

다국어 초록 (Multilingual Abstract)

Artemisia scoparia is an annual grass belonging to the family Asteraceae, distributed in Eurasia, and is a kind of halophyte that grows wild in salt marshes. A. scoparia has been used as anti-hepatitis, diuretic and anti-inflammatory ingredient in folk medicine. Physiological activities such as antioxidant and anti-inflammatory properties of flavonoids and coumarin compounds isolated from A. scoparia have been reported. In this study, the inhibitory effect of A. scoparia on melanogenesis was investigated using its crude extract and solvent fractions (n-hexane, 85% aq. MeOH, n-BuOH and H₂O). Among the solvent fractions obtained from crude extract of A. scoparia, n-hexane and 85% aq. MeOH were the most effective samples in terms of anti-melanogenesis activity. Anti-melanogenic effect of n-hexane and 85% aq. MeOH fractions were confirmed in α-MSH-induced B16F10 melanoma cells via measuring inhibition of the melanogenesis-related factors. Based on the results of this study, it is suggested that A. scoparia has potential to be used as a cosmetic ingredient with melanogenesis inhibitory effects.