0.9% 생리식염수에 의한 희석이 Roc uronium 정주로 인한 회피반응을 감소시키는 데 미치는 영향 = The Effect of Dilution with 0.9% Normal Saline on Reducing Withdrawal Movement Induced by Rocuronium Injection

다국어 초록 (Multilingual Abstract)

Background: The intravenous injection of rocuronium after loss of
consciousness during induction of general anesthesia can cause a
withdrawal movement of hand, arm or more than one extremity. We
designed this study to examine diluted rocuronium (2 mg/ml) with
0.9% normal saline can reduce withdrawal movement.
Methods: Eighty healthy female patients (aged 19-63) scheduled
for general anesthesia were randomly assigned to one of two groups;
Group 1 (rocuronium 10 mg/ml) and Group 2 (rocuronium diluted to
2 mg/ml with 0.9% normal saline). After loss of consciousness and
eyelid reflex by intravenous injection of thiopental sodium 5 mg/kg,
rocuronium (0.6 mg/kg) was injected at the speed of 1 ml/sec in both
groups. The incidence and severity of withdrawal movements were
assessed by using four-point scales.
Results: The incidence and severity of withdrawal movement in
response to rocuronium injection were significantly reduced in Group
2 compared to Group 1 (P ＜ 0.05).
Conclusions: Dilution of rocuronium 10 mg/ml to 2 mg/ml with
0.9% normal saline was significantly effective for reducing withdrawal
movement during induction of general anesthesia. This is a simple
and effective strategy for preventing rocuronium-induced withdrawal
movement.