<P><B>Background</B></P><P>Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de ...
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https://www.riss.kr/link?id=A107675073
Hwang, Joo-Yeon ; Lee, Seung Hun ; Go, Min Jin ; Kim, Beom-Jun ; Kou, Ikuyo ; Ikegawa, Shiro ; Guo, Yan ; Deng, Hong-Wen ; Raychaudhuri, Soumya ; Kim, Young Jin ; Oh, Ji Hee ; Kim, Youngdoe ; Moon, Sanghoon ; Kim, Dong-Joon ; Koo, Heejo ; Cha, My-Jung ; Lee, Min Hye ; Yun, Ji Young ; Yoo, Hye-Sook ; Kang, Young-Ah ; Cho, Eun-Hee ; Kim, Sang-Wook ; Oh, Ki Won ; Kang, Moo Il ; Son, Ho Young ; Kim, Shin-Yoon ; Kim, Ghi Su ; Han, Bok-Ghee ; Cho, Yoon Shin ; Cho, Myeong-Chan ; Lee, Jong-Young ; Koh, Jung-Min
2013
-
SCOPUS,SCIE
학술저널
212-219(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Background</B></P><P>Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de ...
<P><B>Background</B></P><P>Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.</P><P><B>Methods</B></P><P>Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.</P><P><B>Results</B></P><P>In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (<I>rs784288</I> in the <I>MECOM</I> gene) that showed genome-wide significance (p=3.59×10<SUP>−8</SUP>; OR 1.39). RNA interference revealed that a <I>MECOM</I> knockdown suppresses osteoclastogenesis.</P><P><B>Conclusions</B></P><P>Our findings provide new insights into the genetic architecture underlying OF in East Asians.</P>