The MicroRNA‐326: Autoimmune diseases, diagnostic biomarker, and therapeutic target

다국어 초록 (Multilingual Abstract)

MicroRNAs (miRNAs) are uniquely regulated in healthy, inflamed, activated, cancerous, or other cells and tissues of a pathological state. Many studies confirm that immune dysregulation and autoimmune diseases with inflammation are correlated with various miRNA expression changes in targeted tissues and cells in innate or adaptive immunity. In this review, we will explain the history and classification of epigenetic changes. Next, we will describe the role of miRNAs changes, especially mir‐326 in autoimmunity, autoinflammatory, and other pathological conditions. A systematic search of MEDLINE, Embase, and Cochrane Library was presented for all related studies from 1899 to 2017 with restrictions in the English language. In recent years, researchers have concentrated on mostly those roles of miRNA that are correlated with the inflammatory and anti‐inflammatory process. Latest studies have proposed a fundamental pathogenic role in cancers and autoinflammatory diseases. Studies have described the role of microRNAs in autoimmunity and autoinflammatory diseases, cancers, and so on. The miRNA‐326 expression plays a significant role in autoimmune and other types of diseases.
MicroRNAs (miRNAs) are uniquely regulated in healthy, inflamed, activated, and cancerous cells and tissues. Most recently, miR‐326 has been explored widely and has emerged as a key regulator of different biological processes such as metabolism of glucose and lipids; cell growth and proliferation; immune cell lineage obligation; maturation, differentiation, and maintenance of immune homeostasis; TH17 differentiation; as well as dendritic cells function. In this review, we will explain the history and classification of epigenetic changes, especially miRNAs and describe the role of miR‐326 in different pathologic conditions, especially autoimmune diseases.