Reported herein is the first rhodium‐catalyzed [4+2+1] cycloaddition of in situ generated ene/yne‐ene‐allenes and CO to synthesize challenging seven‐membered carbocycles fused with five‐membered rings. This reaction is designed based on the ...
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https://www.riss.kr/link?id=O120448972
2018년
-
1433-7851
1521-3773
SCI;SCIE;SCOPUS
학술저널
15544-15548 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Reported herein is the first rhodium‐catalyzed [4+2+1] cycloaddition of in situ generated ene/yne‐ene‐allenes and CO to synthesize challenging seven‐membered carbocycles fused with five‐membered rings. This reaction is designed based on the ...
Reported herein is the first rhodium‐catalyzed [4+2+1] cycloaddition of in situ generated ene/yne‐ene‐allenes and CO to synthesize challenging seven‐membered carbocycles fused with five‐membered rings. This reaction is designed based on the 1,3‐acyloxy migration of ene/yne‐ene‐propargyl esters to ene/yne‐ene‐allenes, followed by oxidative cyclization, CO insertion, and reductive elimination to form the final [4+2+1] cycloadducts. The possible competing [4+1], [4+2], and [2+2+1] cycloadditions were disfavored, making the present reaction an efficient way to access functionalized 5/7 rings.
Ene/yne‐ene‐allenes and CO: Rhodium‐catalyzed [4+2+1] cycloadditions of in situ generated ene/yne‐ene‐allenes and CO enable the synthesis of challenging seven‐membered carbocycles fused with five‐membered rings. For this method, the ene‐allene, alkene/alkyne, and CO serve as four‐, two‐, and one‐carbon synthons, respectively.