Exposure to Music and Noise During Pregnancy Influences Neurogenesis and Thickness in Motor and Somatosensory Cortex of Rat Pups

다국어 초록 (Multilingual Abstract)

Exposure to Music and Noise During Pregnancy Influences Neurogenesis and Thickness in Motor and Somatosensory Cortex of Rat Pups

Je Wook Shin


Gachon University,
School of Medicine

(Directed by Professor Khae-Hawn Kim)


Purpose
Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups.

Methods
The pregnant rats in the music-applied group were exposed to 65 dB of comfortable music for 1 hour, once per day, from the 15th day of pregnancy until delivery. The pregnant rats in the noise-applied group were exposed to 95 dB of sound from a supersonic sound machine for 1 hour, once per day, from the 15th day of pregnancy until delivery. After birth, the offspring were left undisturbed together with their mother. The rat pups were sacrificed at 21 days after birth.

Results
Exposure to music during pregnancy increased neurogenesis in the motor and somatosensory cortex of rat pups. In contrast, rat pups exposed to noise during pregnancy showed decreased neurogenesis and thickness in the motor and somatosensory cortex.

Conclusions
Our study suggests that music and noise during the developmental period are important factors influencing brain development and urogenital disorders.

목차 (Table of Contents)

• I. INTRODUCTION
• II. MATERIALS AND METHODS
• 1. Animal
• 2. Tissue Preparation
• 3. Immunohistochemistry for BrdU
• 4. Data Analysis
• III. RESULTS
• 1. Influence of Prenatal Music and Noise on Neurogenesis in the Motor Cortex of Rat Pups
• 2. Influence of Prenatal Music and Noise on Layer Thickness in the Motor Cortex of Rat Pups
• 3. Influence of Prenatal Music and Noise on Neurogenesis in the Somatosensory Cortex of Rat Pups
• 4. Influence of Prenatal Music and Noise on Layer Thickness in the Somatosensory Cortex of Rat Pups
• IV. DISCUSSION
• V. CONCLUSION
• REFERENCES