Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?

다국어 초록 (Multilingual Abstract)

In mammals, the auditory system, which includes the cochlea, has a very complex structure harboring many types of cells performing different functions. Among these cells are the auditory hair cells (HCs), which are terminally and well differentiated unique cells which have lost their regenerative potential after development. The auditory HCs are easily damaged by aging as well as during episodes of ototoxicity and acoustic trauma. HCs damages typically occur in the early stage of injury and can result a permanent hearing loss. Recently, there have been tremendous developments from stem cells (SCs) research involving sensorineural hearing loss, but several limitations and obstacles persist in allowing these developments from continuing onto clinical applications. This review discusses the recent advances in SC research in sensorineural hearing loss with the subsequent sections discussing the possible hurdles and limitations that currently preclude their clinical application.

참고문헌 (Reference)

1 Duan M, "Treatment of peripheral sensorineural hearing loss: gene therapy" 11 (11): S51-S56, 2004

2 Lang H, "Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury" 9 : 225-240, 2008

3 조용범, "Transplantation of Neural Differentiated Human Mesenchymal Stem Cells into the Cochlea of an Auditory-neuropathy Guinea Pig Model" 대한의학회 26 (26): 492-498, 2011

4 Shibata SB, "Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae" 223 : 464-472, 2010

5 Batts SA, "Transdifferentiation and its applicability for inner ear therapy" 227 : 41-47, 2007

6 Hildebrand MS, "Survival of partially differentiated mouse embryonic stem cells in the scala media of the guinea pig cochlea" 6 : 341-354, 2005

7 Han Z, "Survival and fate of transplanted embryonic neural stem cells by Atoh1 gene transfer in guinea pigs cochlea" 21 : 490-496, 2010

8 Altschuler RA, "Stem cell transplantation for auditory nerve replacement" 242 : 110-116, 2008

9 Okano T, "Stem cell therapy for the inner ear: recent advances and future directions" 16 : 4-18, 2012

10 Jongkamonwiwat N, "Stem cell based therapy in the inner ear: appropriate donor cell types and routes for transplantation" 11 : 888-897, 2010

11 Chen W, "Restoration of auditory evoked responses by human ES-cell-derived otic progenitors" 490 : 278-282, 2012

12 Izumikawa M, "Response of the flat cochlear epithelium to forced expression of Atoh1" 240 : 52-56, 2008

13 Li H, "Pluripotent stem cells from the adult mouse inner ear" 9 : 1293-1299, 2003

14 Vlastarakos PV, "Papacharalambous G, Tzagaroulakis A, Dazert S. Sensory cell regeneration and stem cells: what we have already achieved in the management of deafness" 29 : 758-768, 2008

15 Parker MA, "Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells" 232 : 29-43, 2007

16 Kamiya K, "Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes" 171 : 214-226, 2007

17 Oshima K, "Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells" 141 : 704-716, 2010

18 White PM, "Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells" 441 : 984-987, 2006

19 Lin V, "Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles" 31 : 15329-15339, 2011

20 Wang Y, "In vitro induction and differentiation of newborn guinea pig hippocampus neural stem cells into cells resembling inner hair cells, using artificial perilymph" 125 : 771-775, 2011

21 Koehler KR, "Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture" 500 : 217-221, 2013

22 Li H, "Generation of hair cells by stepwise differentiation of embryonic stem cells" 100 : 13495-13500, 2003

23 Ishimoto S, "Gene transfer into supporting cells of the organ of Corti" 173 : 187-197, 2002

24 Matsuoka AJ, "Enhanced survival of bone-marrow-derived pluripotent stem cells in an animal model of auditory neuropathy" 117 : 1629-1635, 2007

25 Park YH, "Conditioning the cochlea to facilitate survival and integration of exogenous cells into the auditory epithelium" 22 : 873-880, 2014

26 Izumikawa M, "Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals" 11 : 271-276, 2005

27 Ulfendahl M, "A cell therapy approach to substitute neural elements in the inner ear" 92 : 75-79, 2007